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Unusual Fusion Proteins of HIV-1

Despite its small genome size, the Human Immunodeficiency Virus 1 (HIV-1) is one of the most successful pathogens and has infected more than 70 million people worldwide within the last decades. In total, HIV-1 expresses 16 canonical proteins from only nine genes within its 10 kb genome. Expression o...

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Autores principales: Langer, Simon, Sauter, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220186/
https://www.ncbi.nlm.nih.gov/pubmed/28119676
http://dx.doi.org/10.3389/fmicb.2016.02152
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author Langer, Simon
Sauter, Daniel
author_facet Langer, Simon
Sauter, Daniel
author_sort Langer, Simon
collection PubMed
description Despite its small genome size, the Human Immunodeficiency Virus 1 (HIV-1) is one of the most successful pathogens and has infected more than 70 million people worldwide within the last decades. In total, HIV-1 expresses 16 canonical proteins from only nine genes within its 10 kb genome. Expression of the structural genes gag, pol, and env, the regulatory genes rev and tat and the accessory genes vpu, nef, vpr, and vif enables assembly of the viral particle, regulates viral gene transcription, and equips the virus to evade or counteract host immune responses. In addition to the canonically expressed proteins, a growing number of publications describe the existence of non-canonical fusion proteins in HIV-1 infected cells. Most of them are encoded by the tat-env-rev locus. While the majority of these fusion proteins (e.g., TNV/p28(tev), p18(6Drev), Tat1-Rev2, Tat^8c, p17(tev), or Ref) are the result of alternative splicing events, Tat-T/Vpt is produced upon programmed ribosomal frameshifting, and a Rev1-Vpu fusion protein is expressed due to a nucleotide polymorphism that is unique to certain HIV-1 clade A and C strains. A better understanding of the expression and activity of these non-canonical viral proteins will help to dissect their potential role in viral replication and reveal how HIV-1 optimized the coding potential of its genes. The goal of this review is to provide an overview of previously described HIV-1 fusion proteins and to summarize our current knowledge of their expression patterns and putative functions.
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spelling pubmed-52201862017-01-24 Unusual Fusion Proteins of HIV-1 Langer, Simon Sauter, Daniel Front Microbiol Microbiology Despite its small genome size, the Human Immunodeficiency Virus 1 (HIV-1) is one of the most successful pathogens and has infected more than 70 million people worldwide within the last decades. In total, HIV-1 expresses 16 canonical proteins from only nine genes within its 10 kb genome. Expression of the structural genes gag, pol, and env, the regulatory genes rev and tat and the accessory genes vpu, nef, vpr, and vif enables assembly of the viral particle, regulates viral gene transcription, and equips the virus to evade or counteract host immune responses. In addition to the canonically expressed proteins, a growing number of publications describe the existence of non-canonical fusion proteins in HIV-1 infected cells. Most of them are encoded by the tat-env-rev locus. While the majority of these fusion proteins (e.g., TNV/p28(tev), p18(6Drev), Tat1-Rev2, Tat^8c, p17(tev), or Ref) are the result of alternative splicing events, Tat-T/Vpt is produced upon programmed ribosomal frameshifting, and a Rev1-Vpu fusion protein is expressed due to a nucleotide polymorphism that is unique to certain HIV-1 clade A and C strains. A better understanding of the expression and activity of these non-canonical viral proteins will help to dissect their potential role in viral replication and reveal how HIV-1 optimized the coding potential of its genes. The goal of this review is to provide an overview of previously described HIV-1 fusion proteins and to summarize our current knowledge of their expression patterns and putative functions. Frontiers Media S.A. 2017-01-09 /pmc/articles/PMC5220186/ /pubmed/28119676 http://dx.doi.org/10.3389/fmicb.2016.02152 Text en Copyright © 2017 Langer and Sauter. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Langer, Simon
Sauter, Daniel
Unusual Fusion Proteins of HIV-1
title Unusual Fusion Proteins of HIV-1
title_full Unusual Fusion Proteins of HIV-1
title_fullStr Unusual Fusion Proteins of HIV-1
title_full_unstemmed Unusual Fusion Proteins of HIV-1
title_short Unusual Fusion Proteins of HIV-1
title_sort unusual fusion proteins of hiv-1
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220186/
https://www.ncbi.nlm.nih.gov/pubmed/28119676
http://dx.doi.org/10.3389/fmicb.2016.02152
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