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Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study

The relationship between cumulative exposure to resting heart rate (cumRHR) and mortality remain unclear in the general population. In the Kailuan cohort study, resting heart rate (RHR) was repeatedly measured at baseline and at years 2 and 4 by electrocardiogram among 47,311 adults aged 48.70 ± 11....

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Autores principales: Zhao, Quanhui, Li, Haibin, Wang, Anxin, Guo, Jin, Yu, Junxing, Luo, Yanxia, Chen, Shuohua, Tao, Lixin, Li, Yuqing, Li, Aiping, Guo, Xiuhua, Wu, Shouling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220288/
https://www.ncbi.nlm.nih.gov/pubmed/28067310
http://dx.doi.org/10.1038/srep40212
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author Zhao, Quanhui
Li, Haibin
Wang, Anxin
Guo, Jin
Yu, Junxing
Luo, Yanxia
Chen, Shuohua
Tao, Lixin
Li, Yuqing
Li, Aiping
Guo, Xiuhua
Wu, Shouling
author_facet Zhao, Quanhui
Li, Haibin
Wang, Anxin
Guo, Jin
Yu, Junxing
Luo, Yanxia
Chen, Shuohua
Tao, Lixin
Li, Yuqing
Li, Aiping
Guo, Xiuhua
Wu, Shouling
author_sort Zhao, Quanhui
collection PubMed
description The relationship between cumulative exposure to resting heart rate (cumRHR) and mortality remain unclear in the general population. In the Kailuan cohort study, resting heart rate (RHR) was repeatedly measured at baseline and at years 2 and 4 by electrocardiogram among 47,311 adults aged 48.70 ± 11.68. The cumRHR was defined as the summed average RHR between two consecutive examinations multiplied by the time interval between with two examinations [(beats/min) * year]. A higher RHR was defined as ≥80 beats/min, and the number of visits with a higher RHR was counted. During a median of 4.06 years of follow-up, a total of 1,025 participants died. After adjusting for major traditional cardiovascular risk factors and baseline RHR, the hazard ratio for the highest versus lowest quartile of cumRHR was 1.39 (95% CI: 1.07–1.81) for all-cause mortality. Each 1-SD increment in cumRHR was associated with a 37% (HR: 1.37, 95% CI: 1.23–1.52) increased risk of death and displayed a J-shaped relationship. Compared with no exposure, adults who had a higher RHR at all 3 study visits were associated with a 1.86-fold higher risk (95% CI: 1.33–2.61) of mortality. In summary, cumulative exposure to higher RHR is independently associated with an increased risk of mortality.
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spelling pubmed-52202882017-01-11 Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study Zhao, Quanhui Li, Haibin Wang, Anxin Guo, Jin Yu, Junxing Luo, Yanxia Chen, Shuohua Tao, Lixin Li, Yuqing Li, Aiping Guo, Xiuhua Wu, Shouling Sci Rep Article The relationship between cumulative exposure to resting heart rate (cumRHR) and mortality remain unclear in the general population. In the Kailuan cohort study, resting heart rate (RHR) was repeatedly measured at baseline and at years 2 and 4 by electrocardiogram among 47,311 adults aged 48.70 ± 11.68. The cumRHR was defined as the summed average RHR between two consecutive examinations multiplied by the time interval between with two examinations [(beats/min) * year]. A higher RHR was defined as ≥80 beats/min, and the number of visits with a higher RHR was counted. During a median of 4.06 years of follow-up, a total of 1,025 participants died. After adjusting for major traditional cardiovascular risk factors and baseline RHR, the hazard ratio for the highest versus lowest quartile of cumRHR was 1.39 (95% CI: 1.07–1.81) for all-cause mortality. Each 1-SD increment in cumRHR was associated with a 37% (HR: 1.37, 95% CI: 1.23–1.52) increased risk of death and displayed a J-shaped relationship. Compared with no exposure, adults who had a higher RHR at all 3 study visits were associated with a 1.86-fold higher risk (95% CI: 1.33–2.61) of mortality. In summary, cumulative exposure to higher RHR is independently associated with an increased risk of mortality. Nature Publishing Group 2017-01-09 /pmc/articles/PMC5220288/ /pubmed/28067310 http://dx.doi.org/10.1038/srep40212 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhao, Quanhui
Li, Haibin
Wang, Anxin
Guo, Jin
Yu, Junxing
Luo, Yanxia
Chen, Shuohua
Tao, Lixin
Li, Yuqing
Li, Aiping
Guo, Xiuhua
Wu, Shouling
Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study
title Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study
title_full Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study
title_fullStr Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study
title_full_unstemmed Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study
title_short Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study
title_sort cumulative resting heart rate exposure and risk of all-cause mortality: results from the kailuan cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220288/
https://www.ncbi.nlm.nih.gov/pubmed/28067310
http://dx.doi.org/10.1038/srep40212
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