Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence

Bispecific antibodies are considered attractive bio-therapeutic agents owing to their ability to target two distinct disease mediators. Cross-arm avidity targeting of antigen double-positive cancer cells over single-positive normal tissue is believed to enhance the therapeutic efficacy, restrict maj...

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Detalles Bibliográficos
Autores principales: Mazor, Yariv, Sachsenmeier, Kris F., Yang, Chunning, Hansen, Anna, Filderman, Jessica, Mulgrew, Kathy, Wu, Herren, Dall’Acqua, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220356/
https://www.ncbi.nlm.nih.gov/pubmed/28067257
http://dx.doi.org/10.1038/srep40098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220356/
https://www.ncbi.nlm.nih.gov/pubmed/28067257
http://dx.doi.org/10.1038/srep40098

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