Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [(15)N, D(14)]trimethylphenylammonium (TMPA) has a remarkably long spin–l...

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Detalles Bibliográficos
Autores principales: Nonaka, Hiroshi, Hirano, Masashi, Imakura, Yuki, Takakusagi, Yoichi, Ichikawa, Kazuhiro, Sando, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220364/
https://www.ncbi.nlm.nih.gov/pubmed/28067292
http://dx.doi.org/10.1038/srep40104
Descripción
Sumario:Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [(15)N, D(14)]trimethylphenylammonium (TMPA) has a remarkably long spin–lattice relaxation time (1128 s, 14.1 T, 30 °C, D(2)O) on its (15)N nuclei and achieves a long retention of the hyperpolarized state. [(15)N, D(14)]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by (15)N NMR for over 40 min in phophate-buffered saline (H(2)O, pH 7.4, 37 °C).

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