Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [(15)N, D(14)]trimethylphenylammonium (TMPA) has a remarkably long spin–l...

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Autores principales: Nonaka, Hiroshi, Hirano, Masashi, Imakura, Yuki, Takakusagi, Yoichi, Ichikawa, Kazuhiro, Sando, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220364/
https://www.ncbi.nlm.nih.gov/pubmed/28067292
http://dx.doi.org/10.1038/srep40104
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author Nonaka, Hiroshi
Hirano, Masashi
Imakura, Yuki
Takakusagi, Yoichi
Ichikawa, Kazuhiro
Sando, Shinsuke
author_facet Nonaka, Hiroshi
Hirano, Masashi
Imakura, Yuki
Takakusagi, Yoichi
Ichikawa, Kazuhiro
Sando, Shinsuke
author_sort Nonaka, Hiroshi
collection PubMed
description Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [(15)N, D(14)]trimethylphenylammonium (TMPA) has a remarkably long spin–lattice relaxation time (1128 s, 14.1 T, 30 °C, D(2)O) on its (15)N nuclei and achieves a long retention of the hyperpolarized state. [(15)N, D(14)]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by (15)N NMR for over 40 min in phophate-buffered saline (H(2)O, pH 7.4, 37 °C).
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spelling pubmed-52203642017-01-11 Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State Nonaka, Hiroshi Hirano, Masashi Imakura, Yuki Takakusagi, Yoichi Ichikawa, Kazuhiro Sando, Shinsuke Sci Rep Article Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [(15)N, D(14)]trimethylphenylammonium (TMPA) has a remarkably long spin–lattice relaxation time (1128 s, 14.1 T, 30 °C, D(2)O) on its (15)N nuclei and achieves a long retention of the hyperpolarized state. [(15)N, D(14)]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by (15)N NMR for over 40 min in phophate-buffered saline (H(2)O, pH 7.4, 37 °C). Nature Publishing Group 2017-01-09 /pmc/articles/PMC5220364/ /pubmed/28067292 http://dx.doi.org/10.1038/srep40104 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Nonaka, Hiroshi
Hirano, Masashi
Imakura, Yuki
Takakusagi, Yoichi
Ichikawa, Kazuhiro
Sando, Shinsuke
Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State
title Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State
title_full Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State
title_fullStr Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State
title_full_unstemmed Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State
title_short Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State
title_sort design of a (15)n molecular unit to achieve long retention of hyperpolarized spin state
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220364/
https://www.ncbi.nlm.nih.gov/pubmed/28067292
http://dx.doi.org/10.1038/srep40104
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