Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?

Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in precarcinogen metabolism; for this reason it is relevant to know more in depth the mechanisms that rule out its expression and activity, which make this enzyme a target for the development of novel chemiopreventive ag...

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Detalles Bibliográficos
Autores principales: Santes-Palacios, Rebeca, Ornelas-Ayala, Diego, Cabañas, Noel, Marroquín-Pérez, Ana, Hernández-Magaña, Alexis, del Rosario Olguín-Reyes, Sitlali, Camacho-Carranza, Rafael, Espinosa-Aguirre, Jesús Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220472/
https://www.ncbi.nlm.nih.gov/pubmed/28105425
http://dx.doi.org/10.1155/2016/5341081
Descripción
Sumario:Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in precarcinogen metabolism; for this reason it is relevant to know more in depth the mechanisms that rule out its expression and activity, which make this enzyme a target for the development of novel chemiopreventive agents. The aim of this work is to review the origin, regulation, and structural and functional characteristics of CYP1A1 letting us understand its role in the bioactivation of precarcinogen and the consequences of its modulation in other physiological processes, as well as guide us in the study of this important protein.

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