Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?

Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in precarcinogen metabolism; for this reason it is relevant to know more in depth the mechanisms that rule out its expression and activity, which make this enzyme a target for the development of novel chemiopreventive ag...

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Autores principales: Santes-Palacios, Rebeca, Ornelas-Ayala, Diego, Cabañas, Noel, Marroquín-Pérez, Ana, Hernández-Magaña, Alexis, del Rosario Olguín-Reyes, Sitlali, Camacho-Carranza, Rafael, Espinosa-Aguirre, Jesús Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220472/
https://www.ncbi.nlm.nih.gov/pubmed/28105425
http://dx.doi.org/10.1155/2016/5341081
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author Santes-Palacios, Rebeca
Ornelas-Ayala, Diego
Cabañas, Noel
Marroquín-Pérez, Ana
Hernández-Magaña, Alexis
del Rosario Olguín-Reyes, Sitlali
Camacho-Carranza, Rafael
Espinosa-Aguirre, Jesús Javier
author_facet Santes-Palacios, Rebeca
Ornelas-Ayala, Diego
Cabañas, Noel
Marroquín-Pérez, Ana
Hernández-Magaña, Alexis
del Rosario Olguín-Reyes, Sitlali
Camacho-Carranza, Rafael
Espinosa-Aguirre, Jesús Javier
author_sort Santes-Palacios, Rebeca
collection PubMed
description Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in precarcinogen metabolism; for this reason it is relevant to know more in depth the mechanisms that rule out its expression and activity, which make this enzyme a target for the development of novel chemiopreventive agents. The aim of this work is to review the origin, regulation, and structural and functional characteristics of CYP1A1 letting us understand its role in the bioactivation of precarcinogen and the consequences of its modulation in other physiological processes, as well as guide us in the study of this important protein.
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spelling pubmed-52204722017-01-19 Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention? Santes-Palacios, Rebeca Ornelas-Ayala, Diego Cabañas, Noel Marroquín-Pérez, Ana Hernández-Magaña, Alexis del Rosario Olguín-Reyes, Sitlali Camacho-Carranza, Rafael Espinosa-Aguirre, Jesús Javier Biomed Res Int Review Article Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in precarcinogen metabolism; for this reason it is relevant to know more in depth the mechanisms that rule out its expression and activity, which make this enzyme a target for the development of novel chemiopreventive agents. The aim of this work is to review the origin, regulation, and structural and functional characteristics of CYP1A1 letting us understand its role in the bioactivation of precarcinogen and the consequences of its modulation in other physiological processes, as well as guide us in the study of this important protein. Hindawi Publishing Corporation 2016 2016-12-26 /pmc/articles/PMC5220472/ /pubmed/28105425 http://dx.doi.org/10.1155/2016/5341081 Text en Copyright © 2016 Rebeca Santes-Palacios et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Santes-Palacios, Rebeca
Ornelas-Ayala, Diego
Cabañas, Noel
Marroquín-Pérez, Ana
Hernández-Magaña, Alexis
del Rosario Olguín-Reyes, Sitlali
Camacho-Carranza, Rafael
Espinosa-Aguirre, Jesús Javier
Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?
title Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?
title_full Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?
title_fullStr Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?
title_full_unstemmed Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?
title_short Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?
title_sort regulation of human cytochrome p4501a1 (hcyp1a1): a plausible target for chemoprevention?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220472/
https://www.ncbi.nlm.nih.gov/pubmed/28105425
http://dx.doi.org/10.1155/2016/5341081
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