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Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra-Abdominal Adhesion Formation in a Rat Model

The intestine function recovery decoction (IFRD) is a traditional Chinese medicine that has been used for the treatment of adhesive intestinal obstruction. In this study, the preventative effects and probable mechanism of the IFRD were investigated in a rat model. We randomly assigned rats to five g...

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Autores principales: Zhou, Cancan, Jia, Pengbo, Jiang, Zhengdong, Chen, Ke, Wang, Guanghui, Wang, Kang, Wei, Guangbing, Li, Xuqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220493/
https://www.ncbi.nlm.nih.gov/pubmed/28105058
http://dx.doi.org/10.1155/2016/1621894
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author Zhou, Cancan
Jia, Pengbo
Jiang, Zhengdong
Chen, Ke
Wang, Guanghui
Wang, Kang
Wei, Guangbing
Li, Xuqi
author_facet Zhou, Cancan
Jia, Pengbo
Jiang, Zhengdong
Chen, Ke
Wang, Guanghui
Wang, Kang
Wei, Guangbing
Li, Xuqi
author_sort Zhou, Cancan
collection PubMed
description The intestine function recovery decoction (IFRD) is a traditional Chinese medicine that has been used for the treatment of adhesive intestinal obstruction. In this study, the preventative effects and probable mechanism of the IFRD were investigated in a rat model. We randomly assigned rats to five groups: normal, model, control, low dose IFRD, and high dose IFRD. In the animal model, the caecum wall and parietal peritoneum were abraded to induce intra-abdominal adhesion formation. Seven days after surgery, adhesion scores were assessed using a visual scoring system, and histopathological samples were examined. The levels of serum interleukin-6 (IL-6) and transforming growth factor beta-1 (TGF-β1) were analysed by an enzyme-linked immunosorbent assay (ELISA). The results showed that a high dose of IFRD reduced the grade of intra-abdominal adhesion in rats. Furthermore, the grades of inflammation, fibrosis, and neovascularization in the high dose IFRD group were significantly lower than those in the control group. The results indicate that the IFRD can prevent intra-abdominal adhesion formation in a rat model. These data suggest that the IFRD may be an effective antiadhesion agent.
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spelling pubmed-52204932017-01-19 Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra-Abdominal Adhesion Formation in a Rat Model Zhou, Cancan Jia, Pengbo Jiang, Zhengdong Chen, Ke Wang, Guanghui Wang, Kang Wei, Guangbing Li, Xuqi Evid Based Complement Alternat Med Research Article The intestine function recovery decoction (IFRD) is a traditional Chinese medicine that has been used for the treatment of adhesive intestinal obstruction. In this study, the preventative effects and probable mechanism of the IFRD were investigated in a rat model. We randomly assigned rats to five groups: normal, model, control, low dose IFRD, and high dose IFRD. In the animal model, the caecum wall and parietal peritoneum were abraded to induce intra-abdominal adhesion formation. Seven days after surgery, adhesion scores were assessed using a visual scoring system, and histopathological samples were examined. The levels of serum interleukin-6 (IL-6) and transforming growth factor beta-1 (TGF-β1) were analysed by an enzyme-linked immunosorbent assay (ELISA). The results showed that a high dose of IFRD reduced the grade of intra-abdominal adhesion in rats. Furthermore, the grades of inflammation, fibrosis, and neovascularization in the high dose IFRD group were significantly lower than those in the control group. The results indicate that the IFRD can prevent intra-abdominal adhesion formation in a rat model. These data suggest that the IFRD may be an effective antiadhesion agent. Hindawi Publishing Corporation 2016 2016-12-26 /pmc/articles/PMC5220493/ /pubmed/28105058 http://dx.doi.org/10.1155/2016/1621894 Text en Copyright © 2016 Cancan Zhou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Cancan
Jia, Pengbo
Jiang, Zhengdong
Chen, Ke
Wang, Guanghui
Wang, Kang
Wei, Guangbing
Li, Xuqi
Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra-Abdominal Adhesion Formation in a Rat Model
title Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra-Abdominal Adhesion Formation in a Rat Model
title_full Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra-Abdominal Adhesion Formation in a Rat Model
title_fullStr Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra-Abdominal Adhesion Formation in a Rat Model
title_full_unstemmed Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra-Abdominal Adhesion Formation in a Rat Model
title_short Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra-Abdominal Adhesion Formation in a Rat Model
title_sort preventive effects of the intestine function recovery decoction, a traditional chinese medicine, on postoperative intra-abdominal adhesion formation in a rat model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220493/
https://www.ncbi.nlm.nih.gov/pubmed/28105058
http://dx.doi.org/10.1155/2016/1621894
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