HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet. Here, we assessed the potential therapeutic effect o...

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Detalles Bibliográficos
Autores principales: Kim, Ji-Yon, Woo, So-Youn, Hong, Young Bin, Choi, Heesun, Kim, Jisoo, Choi, Hyunjung, Mook-Jung, Inhee, Ha, Nina, Kyung, Jangbeen, Koo, Soo Kyung, Jung, Sung-Chul, Choi, Byung-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220520/
https://www.ncbi.nlm.nih.gov/pubmed/28105056
http://dx.doi.org/10.1155/2016/9475981

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