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Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain

OBJECTIVE: IP6 kinases (IP6Ks) regulate cell metabolism and survival. Mice with global (IP6K1-KO) or adipocyte-specific (AdKO) deletion of IP6K1 are protected from diet induced obesity (DIO) at ambient (23 °C) temperature. AdKO mice are lean primarily due to increased AMPK mediated thermogenic energ...

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Detalles Bibliográficos
Autores principales:	Zhu, Qingzhang, Ghoshal, Sarbani, Tyagi, Richa, Chakraborty, Anutosh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220553/ https://www.ncbi.nlm.nih.gov/pubmed/28123939 http://dx.doi.org/10.1016/j.molmet.2016.11.010

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