Cargando…

Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype

OBJECTIVE: Parkinson's disease (PD) presents clinically with several motor subtypes that exhibit variable treatment response and prognosis. Here, we investigated genetic variants for their potential association with PD motor phenotype and progression. METHODS: We screened 10 SNPs, previously as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cooper, Christine A., Jain, Nimansha, Gallagher, Michael D., Weintraub, Daniel, Xie, Sharon X., Berlyand, Yosef, Espay, Alberto J., Quinn, Joseph, Edwards, Karen L., Montine, Thomas, Van Deerlin, Vivianna M., Trojanowski, John, Zabetian, Cyrus P., Chen‐Plotkin, Alice S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221454/ https://www.ncbi.nlm.nih.gov/pubmed/28078311 http://dx.doi.org/10.1002/acn3.371

Ejemplares similares

The Parkinson’s disease variant rs356182 regulates neuronal differentiation independently from alpha-synuclein
por: Prahl, Jordan D, et al.
Publicado: (2022)

Genetic prediction of impulse control disorders in Parkinson's disease
por: Weintraub, Daniel, et al.
Publicado: (2022)

The Effects of SNCA rs894278 on Resting-State Brain Activity in Parkinson’s Disease
por: Zhang, Kailin, et al.
Publicado: (2019)

Metal Exposure and SNCA rs356219 Polymorphism Associated With Parkinson Disease and Parkinsonism
por: Lucchini, Roberto G., et al.
Publicado: (2020)

An Alzheimer’s Disease-Derived Biomarker Signature Identifies Parkinson’s Disease Patients with Dementia
por: Berlyand, Yosef, et al.
Publicado: (2016)

Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074
por: Shu, Li, et al.
Publicado: (2018)

Convergent Approaches for Defining Functional Imaging Endophenotypes in Schizophrenia
por: Pearlson, Godfrey D., et al.
Publicado: (2009)

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain
por: Busch, Johanna I, et al.
Publicado: (2013)

Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia
por: Akhtar, Rizwan S., et al.
Publicado: (2017)

Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from SNCA rs356168
por: Glenn, Omolara-Chinue, et al.
Publicado: (2017)

SNCA rs3910105 Is Associated With Development of Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease
por: Yang, Nan-nan, et al.
Publicado: (2022)

The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson’s Disease and SNCA Gene Methylation
por: Iakovenko, E. V., et al.
Publicado: (2020)

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation
por: Kiely, Aoife P., et al.
Publicado: (2015)

Neurocognitive Endophenotypes of Schizophrenia and Bipolar Disorder and Possible Associations with FKBP Variant rs3800373
por: Memic, Amra, et al.
Publicado: (2018)

SNCA-AS1 in aging and Parkinson’s disease
por: Carelli, Stephana, et al.
Publicado: (2022)

Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson’s disease cohort
por: Loesch, Douglas P., et al.
Publicado: (2022)

Association of the SNP rs112369934 near TRIM66 Gene with POAG Endophenotypes in African Americans
por: Kim, Claire D., et al.
Publicado: (2021)

Testing for Allele-specific Expression from Human Brain Samples
por: Diaz-Ortiz, Maria E., et al.
Publicado: (2023)

Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated
por: Robinson, John L, et al.
Publicado: (2023)

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis
por: Brettschneider, Johannes, et al.
Publicado: (2012)

Alzheimer's genetic risk is reduced in primary age‐related tauopathy: a potential model of resistance?
por: McMillan, Corey T., et al.
Publicado: (2018)

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss
por: Feng, Tuancheng, et al.
Publicado: (2022)

Alcoholism: the dissection for endophenotypes
por: Hines, Lisa M., et al.
Publicado: (2005)

Endophenotypes in the personality disorders
por: Siever, Larry J.
Publicado: (2005)

Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes
por: O'Regan, Gráinne M., et al.
Publicado: (2010)

PolyQ Repeat Expansions in ATXN2 Associated with ALS Are CAA Interrupted Repeats
por: Yu, Zhenming, et al.
Publicado: (2011)

Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease
por: Luo, Ningdi, et al.
Publicado: (2019)

Hyposmia Is Associated with RBD for PD Patients with Variants of SNCA
por: Li, Yuanyuan, et al.
Publicado: (2017)

Prognostic significance of SNCA and its methylation in bladder cancer
por: Wu, Zhengcun, et al.
Publicado: (2022)

Neuronal SNCA transcription during Lewy body formation
por: Kon, Tomoya, et al.
Publicado: (2023)

Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease
por: Palmer, William C., et al.
Publicado: (2021)

Woman with atraumatic violaceous thigh discoloration
por: Berlyand, Yosef, et al.
Publicado: (2020)

Prediction of cognitive progression in Parkinson's disease using three cognitive screening measures
por: Kim, Hojoong M., et al.
Publicado: (2019)

The endophenotype concept in psychiatric genetics
por: FLINT, JONATHAN, et al.
Publicado: (2007)

Evaluating endophenotypes for bipolar disorder
por: Guglielmo, Riccardo, et al.
Publicado: (2021)

Endophenotypic effects of the SORL1 variant rs2298813 on regional brain volume in patients with late-onset Alzheimer’s disease
por: Chen, Chun-Yu, et al.
Publicado: (2022)

Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
por: Kang, Wenyan, et al.
Publicado: (2016)

Evaluation of the Role of SNCA Variants in Survival without Neurological Disease
por: Heckman, Michael G., et al.
Publicado: (2012)

Mutations in PRKN and SNCA Genes Important for the Progress of Parkinson’s Disease
por: Oczkowska, Anna, et al.
Publicado: (2013)

SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma
por: Yan, Yuanliang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_u1jvt0q79hllglr05b8lue0ft5