Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

OBJECTIVE: Prostaglandin E(2) (PGE(2)) synthesis is modulated by COX2. Changes in PGE(2) could be used to quantify the COX2 inhibition after ibuprofen administration. This study investigated the pharmacokinetic and pharmacodynamic relationships for COX2 inhibition according to three formulations of...

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Detalles Bibliográficos
Autores principales: Shin, Dongseong, Lee, Sook Joung, Ha, Yu-Mi, Choi, Young-Sim, Kim, Jae-Won, Park, Se-Rin, Park, Min Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221548/
https://www.ncbi.nlm.nih.gov/pubmed/28115830
http://dx.doi.org/10.2147/DDDT.S121633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221548/
https://www.ncbi.nlm.nih.gov/pubmed/28115830
http://dx.doi.org/10.2147/DDDT.S121633

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