α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

During spreading and migration, the leading edges of cells undergo periodic protrusion–retraction cycles. The functional purpose of these cycles is unclear. Here, using submicrometer polydimethylsiloxane pillars as substrates for cell spreading, we show that periodic edge retractions coincide with p...

Descripción completa

Detalles Bibliográficos
Autores principales: Meacci, Giovanni, Wolfenson, Haguy, Liu, Shuaimin, Stachowiak, Matthew R., Iskratsch, Thomas, Mathur, Anurag, Ghassemi, Saba, Gauthier, Nils, Tabdanov, Erdem, Lohner, James, Gondarenko, Alexander, Chander, Ashok C., Roca-Cusachs, Pere, O’Shaughnessy, Ben, Hone, James, Sheetz, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221581/
https://www.ncbi.nlm.nih.gov/pubmed/27122603
http://dx.doi.org/10.1091/mbc.E16-02-0107

Ejemplares similares

Ejemplares similares