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Virtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic disease

In autosomal dominant polycystic kidney disease (ADPKD), cysts accumulate and progressively impair renal function. Mutations in PKD1 and PKD2 genes are causally linked to ADPKD, but how these mutations drive cell behaviors that underlie ADPKD pathogenesis is unknown. Human ADPKD cysts frequently exp...

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Detalles Bibliográficos
Autores principales:	Belmonte, Julio M., Clendenon, Sherry G., Oliveira, Guilherme M., Swat, Maciej H., Greene, Evan V., Jeyaraman, Srividhya, Glazier, James A., Bacallao, Robert L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221598/ https://www.ncbi.nlm.nih.gov/pubmed/27193300 http://dx.doi.org/10.1091/mbc.E16-01-0059

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