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FICD acts bi-functionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP

Protein folding homeostasis in the endoplasmic reticulum (ER) is defended by an unfolded protein response (UPR) that matches ER chaperone capacity to the burden of unfolded proteins. As levels of unfolded proteins decline, a metazoan-specific FIC-domain containing ER-localized enzyme, FICD (HYPE), r...

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Detalles Bibliográficos
Autores principales:	Preissler, Steffen, Rato, Claudia, Perera, Luke, Saudek, Vladimir, Ron, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221731/ https://www.ncbi.nlm.nih.gov/pubmed/27918543 http://dx.doi.org/10.1038/nsmb.3337

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