Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase

DNA repair by homologous recombination (HR) underpins cell survival and fuels genome instability, cancer, and evolution. However, the main kinds and sources of DNA damage repaired by HR in somatic cells and the roles of important HR proteins remain elusive. We present engineered proteins that trap,...

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Detalles Bibliográficos
Autores principales: Xia, Jun, Chen, Li-Tzu, Mei, Qian, Ma, Chien-Hui, Halliday, Jennifer A., Lin, Hsin-Yu, Magnan, David, Pribis, John P., Fitzgerald, Devon M., Hamilton, Holly M., Richters, Megan, Nehring, Ralf B., Shen, Xi, Li, Lei, Bates, David, Hastings, P. J., Herman, Christophe, Jayaram, Makkuni, Rosenberg, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222578/
https://www.ncbi.nlm.nih.gov/pubmed/28090586
http://dx.doi.org/10.1126/sciadv.1601605

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