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A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible

Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history...

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Autores principales: Soo, Joanne, Kokosis, George, Ogilvie, Michael, “Sara” Jiang, Xiaoyin, Powers, David B., Rocke, Daniel J., Erdmann, Detlev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222637/
https://www.ncbi.nlm.nih.gov/pubmed/28293492
http://dx.doi.org/10.1097/GOX.0000000000001070
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author Soo, Joanne
Kokosis, George
Ogilvie, Michael
“Sara” Jiang, Xiaoyin
Powers, David B.
Rocke, Daniel J.
Erdmann, Detlev
author_facet Soo, Joanne
Kokosis, George
Ogilvie, Michael
“Sara” Jiang, Xiaoyin
Powers, David B.
Rocke, Daniel J.
Erdmann, Detlev
author_sort Soo, Joanne
collection PubMed
description Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy. She then developed a recurrence of the mandibular alveolar ridge. The patient was successfully treated with a composite resection including a segmental mandibulectomy, buccal mucosa resection, partial glossectomy, and ipsilateral neck dissection. This was reconstructed with a free fibula osteo-septo-cutaneous flap. Mandibular OSCC is a rare complication of OLP with few reports on effective reconstructive interventions. The case represents the youngest reported patient with mandibular OSCC arising in the context of OLP and highlights the utility of the free vascularized fibula graft in the treatment of these patients.
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spelling pubmed-52226372017-03-14 A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible Soo, Joanne Kokosis, George Ogilvie, Michael “Sara” Jiang, Xiaoyin Powers, David B. Rocke, Daniel J. Erdmann, Detlev Plast Reconstr Surg Glob Open Case Report Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy. She then developed a recurrence of the mandibular alveolar ridge. The patient was successfully treated with a composite resection including a segmental mandibulectomy, buccal mucosa resection, partial glossectomy, and ipsilateral neck dissection. This was reconstructed with a free fibula osteo-septo-cutaneous flap. Mandibular OSCC is a rare complication of OLP with few reports on effective reconstructive interventions. The case represents the youngest reported patient with mandibular OSCC arising in the context of OLP and highlights the utility of the free vascularized fibula graft in the treatment of these patients. Wolters Kluwer Health 2016-12-23 /pmc/articles/PMC5222637/ /pubmed/28293492 http://dx.doi.org/10.1097/GOX.0000000000001070 Text en Copyright © 2016 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Soo, Joanne
Kokosis, George
Ogilvie, Michael
“Sara” Jiang, Xiaoyin
Powers, David B.
Rocke, Daniel J.
Erdmann, Detlev
A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible
title A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible
title_full A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible
title_fullStr A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible
title_full_unstemmed A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible
title_short A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible
title_sort rare case of malignant transformation of oral lichen planus of the mandible
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222637/
https://www.ncbi.nlm.nih.gov/pubmed/28293492
http://dx.doi.org/10.1097/GOX.0000000000001070
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