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A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible
Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222637/ https://www.ncbi.nlm.nih.gov/pubmed/28293492 http://dx.doi.org/10.1097/GOX.0000000000001070 |
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author | Soo, Joanne Kokosis, George Ogilvie, Michael “Sara” Jiang, Xiaoyin Powers, David B. Rocke, Daniel J. Erdmann, Detlev |
author_facet | Soo, Joanne Kokosis, George Ogilvie, Michael “Sara” Jiang, Xiaoyin Powers, David B. Rocke, Daniel J. Erdmann, Detlev |
author_sort | Soo, Joanne |
collection | PubMed |
description | Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy. She then developed a recurrence of the mandibular alveolar ridge. The patient was successfully treated with a composite resection including a segmental mandibulectomy, buccal mucosa resection, partial glossectomy, and ipsilateral neck dissection. This was reconstructed with a free fibula osteo-septo-cutaneous flap. Mandibular OSCC is a rare complication of OLP with few reports on effective reconstructive interventions. The case represents the youngest reported patient with mandibular OSCC arising in the context of OLP and highlights the utility of the free vascularized fibula graft in the treatment of these patients. |
format | Online Article Text |
id | pubmed-5222637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-52226372017-03-14 A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible Soo, Joanne Kokosis, George Ogilvie, Michael “Sara” Jiang, Xiaoyin Powers, David B. Rocke, Daniel J. Erdmann, Detlev Plast Reconstr Surg Glob Open Case Report Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy. She then developed a recurrence of the mandibular alveolar ridge. The patient was successfully treated with a composite resection including a segmental mandibulectomy, buccal mucosa resection, partial glossectomy, and ipsilateral neck dissection. This was reconstructed with a free fibula osteo-septo-cutaneous flap. Mandibular OSCC is a rare complication of OLP with few reports on effective reconstructive interventions. The case represents the youngest reported patient with mandibular OSCC arising in the context of OLP and highlights the utility of the free vascularized fibula graft in the treatment of these patients. Wolters Kluwer Health 2016-12-23 /pmc/articles/PMC5222637/ /pubmed/28293492 http://dx.doi.org/10.1097/GOX.0000000000001070 Text en Copyright © 2016 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Case Report Soo, Joanne Kokosis, George Ogilvie, Michael “Sara” Jiang, Xiaoyin Powers, David B. Rocke, Daniel J. Erdmann, Detlev A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible |
title | A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible |
title_full | A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible |
title_fullStr | A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible |
title_full_unstemmed | A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible |
title_short | A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible |
title_sort | rare case of malignant transformation of oral lichen planus of the mandible |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222637/ https://www.ncbi.nlm.nih.gov/pubmed/28293492 http://dx.doi.org/10.1097/GOX.0000000000001070 |
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