Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines

Lysosomes have traditionally been viewed as degradative organelles, although a growing body of evidence suggests that they can function as Ca(2+) stores. Here we examined the function of these stores in hippocampal pyramidal neurons. We found that back-propagating action potentials (bpAPs) could eli...

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Detalles Bibliográficos
Autores principales: Padamsey, Zahid, McGuinness, Lindsay, Bardo, Scott J., Reinhart, Marcia, Tong, Rudi, Hedegaard, Anne, Hart, Michael L., Emptage, Nigel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222721/
https://www.ncbi.nlm.nih.gov/pubmed/27989455
http://dx.doi.org/10.1016/j.neuron.2016.11.013

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