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How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication
The eukaryotic replisome is a molecular machine that coordinates the Cdc45-MCM-GINS (CMG) replicative DNA helicase with DNA polymerases α, δ, and ε and other proteins to copy the leading- and lagging-strand templates at rates between 1 and 2 kb min(−1). We have now reconstituted this sophisticated m...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222725/ https://www.ncbi.nlm.nih.gov/pubmed/27989442 http://dx.doi.org/10.1016/j.molcel.2016.11.017 |