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The Effectiveness and Safety of Topical Capsaicin in Postherpetic Neuralgia: A Systematic Review and Meta-analysis

In particular, neuropathic pain is a major form of chronic pain. This type of pain results from dysfunction or lesions in the central and peripheral nervous system. Capsaicin has been traditionally utilized as a medicine to remedy pain. However, the effectiveness and safety of this practice is still...

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Autores principales: Yong, Yi Lai, Tan, Loh Teng-Hern, Ming, Long Chiau, Chan, Kok-Gan, Lee, Learn-Han, Goh, Bey-Hing, Khan, Tahir Mehmood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222862/
https://www.ncbi.nlm.nih.gov/pubmed/28119613
http://dx.doi.org/10.3389/fphar.2016.00538
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author Yong, Yi Lai
Tan, Loh Teng-Hern
Ming, Long Chiau
Chan, Kok-Gan
Lee, Learn-Han
Goh, Bey-Hing
Khan, Tahir Mehmood
author_facet Yong, Yi Lai
Tan, Loh Teng-Hern
Ming, Long Chiau
Chan, Kok-Gan
Lee, Learn-Han
Goh, Bey-Hing
Khan, Tahir Mehmood
author_sort Yong, Yi Lai
collection PubMed
description In particular, neuropathic pain is a major form of chronic pain. This type of pain results from dysfunction or lesions in the central and peripheral nervous system. Capsaicin has been traditionally utilized as a medicine to remedy pain. However, the effectiveness and safety of this practice is still elusive. Therefore, this systematic review aimed to investigate the effect of topical capsaicin as a pain-relieving agent that is frequently used in pain management. In brief, all the double-blinded, randomized placebo- or vehicle-controlled trials that were published in English addressing postherpetic neuralgia were included. Meta-analysis was performed using Revman(®) version 5.3. Upon application of the inclusion and exclusion criteria, only six trials fulfilled all the criteria and were included in the review for qualitative analysis. The difference in mean percentage change in numeric pain rating scale score ranges from -31 to -4.3. This demonstrated high efficacy of topical capsaicin application and implies that capsaicin could result in pain reduction. Furthermore, meta-analysis was performed on five of the included studies. All the results of studies are in favor of the treatment using capsaicin. The incidence of side effects from using topical capsaicin is consistently higher in all included studies, but the significance of safety data cannot be quantified due to a lack of p-values in the original studies. Nevertheless, topical capsaicin is a promising treatment option for specific patient groups or certain neuropathic pain conditions such as postherpetic neuralgia.
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spelling pubmed-52228622017-01-24 The Effectiveness and Safety of Topical Capsaicin in Postherpetic Neuralgia: A Systematic Review and Meta-analysis Yong, Yi Lai Tan, Loh Teng-Hern Ming, Long Chiau Chan, Kok-Gan Lee, Learn-Han Goh, Bey-Hing Khan, Tahir Mehmood Front Pharmacol Pharmacology In particular, neuropathic pain is a major form of chronic pain. This type of pain results from dysfunction or lesions in the central and peripheral nervous system. Capsaicin has been traditionally utilized as a medicine to remedy pain. However, the effectiveness and safety of this practice is still elusive. Therefore, this systematic review aimed to investigate the effect of topical capsaicin as a pain-relieving agent that is frequently used in pain management. In brief, all the double-blinded, randomized placebo- or vehicle-controlled trials that were published in English addressing postherpetic neuralgia were included. Meta-analysis was performed using Revman(®) version 5.3. Upon application of the inclusion and exclusion criteria, only six trials fulfilled all the criteria and were included in the review for qualitative analysis. The difference in mean percentage change in numeric pain rating scale score ranges from -31 to -4.3. This demonstrated high efficacy of topical capsaicin application and implies that capsaicin could result in pain reduction. Furthermore, meta-analysis was performed on five of the included studies. All the results of studies are in favor of the treatment using capsaicin. The incidence of side effects from using topical capsaicin is consistently higher in all included studies, but the significance of safety data cannot be quantified due to a lack of p-values in the original studies. Nevertheless, topical capsaicin is a promising treatment option for specific patient groups or certain neuropathic pain conditions such as postherpetic neuralgia. Frontiers Media S.A. 2017-01-10 /pmc/articles/PMC5222862/ /pubmed/28119613 http://dx.doi.org/10.3389/fphar.2016.00538 Text en Copyright © 2017 Yong, Tan, Ming, Chan, Lee, Goh and Khan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yong, Yi Lai
Tan, Loh Teng-Hern
Ming, Long Chiau
Chan, Kok-Gan
Lee, Learn-Han
Goh, Bey-Hing
Khan, Tahir Mehmood
The Effectiveness and Safety of Topical Capsaicin in Postherpetic Neuralgia: A Systematic Review and Meta-analysis
title The Effectiveness and Safety of Topical Capsaicin in Postherpetic Neuralgia: A Systematic Review and Meta-analysis
title_full The Effectiveness and Safety of Topical Capsaicin in Postherpetic Neuralgia: A Systematic Review and Meta-analysis
title_fullStr The Effectiveness and Safety of Topical Capsaicin in Postherpetic Neuralgia: A Systematic Review and Meta-analysis
title_full_unstemmed The Effectiveness and Safety of Topical Capsaicin in Postherpetic Neuralgia: A Systematic Review and Meta-analysis
title_short The Effectiveness and Safety of Topical Capsaicin in Postherpetic Neuralgia: A Systematic Review and Meta-analysis
title_sort effectiveness and safety of topical capsaicin in postherpetic neuralgia: a systematic review and meta-analysis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222862/
https://www.ncbi.nlm.nih.gov/pubmed/28119613
http://dx.doi.org/10.3389/fphar.2016.00538
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