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Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland

It has been shown that metastases to the thyroid from extrathyroidal malignancies occur as solitary or multiple nodules, or may involve the whole thyroid gland diffusely. However, diffuse metastasis of gastric cancer to the thyroid is extremely rare. Here, we report a case of a 74-year-old woman wit...

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Autores principales: Morita, Koji, Sakamoto, Takahiko, Ota, Shuji, Masugi, Hideo, Chikuta, Ikumi, Mashimo, Yamato, Edo, Naoki, Tokairin, Takuo, Seki, Nobuhiko, Ishikawa, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222898/
https://www.ncbi.nlm.nih.gov/pubmed/27696013
http://dx.doi.org/10.1007/s10396-016-0746-5
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author Morita, Koji
Sakamoto, Takahiko
Ota, Shuji
Masugi, Hideo
Chikuta, Ikumi
Mashimo, Yamato
Edo, Naoki
Tokairin, Takuo
Seki, Nobuhiko
Ishikawa, Toshio
author_facet Morita, Koji
Sakamoto, Takahiko
Ota, Shuji
Masugi, Hideo
Chikuta, Ikumi
Mashimo, Yamato
Edo, Naoki
Tokairin, Takuo
Seki, Nobuhiko
Ishikawa, Toshio
author_sort Morita, Koji
collection PubMed
description It has been shown that metastases to the thyroid from extrathyroidal malignancies occur as solitary or multiple nodules, or may involve the whole thyroid gland diffusely. However, diffuse metastasis of gastric cancer to the thyroid is extremely rare. Here, we report a case of a 74-year-old woman with diffuse infiltration of gastric adenocarcinoma (signet-ring-cell carcinoma/poorly differentiated adenocarcinoma) cells in the thyroid. The pathological diagnosis was made based on upper gastrointestinal endoscopy with biopsy and fine-needle aspiration cytology of the thyroid. An 18F-FDG PET/CT revealed multiple lesions with increased uptake, including the bilateral thyroid gland. On thyroid ultrasound examination, diffuse enlargement with internal heterogeneity and hypoechoic reticular lines was observed. On color Doppler imaging, a blood-flow signal was not detected in these hypoechoic lines. These findings were similar to those of diffuse metastases caused by other primary cancers, such as lung cancer, as reported earlier. Therefore, the presence of hypoechoic reticular lines without blood-flow signals is probably common to diffuse thyroid metastasis from any origin and an important diagnostic finding. This is the first report to show detailed ultrasound findings of diffuse gastric cancer metastasis to the thyroid gland using color Doppler.
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spelling pubmed-52228982017-01-19 Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland Morita, Koji Sakamoto, Takahiko Ota, Shuji Masugi, Hideo Chikuta, Ikumi Mashimo, Yamato Edo, Naoki Tokairin, Takuo Seki, Nobuhiko Ishikawa, Toshio J Med Ultrason (2001) Case Report It has been shown that metastases to the thyroid from extrathyroidal malignancies occur as solitary or multiple nodules, or may involve the whole thyroid gland diffusely. However, diffuse metastasis of gastric cancer to the thyroid is extremely rare. Here, we report a case of a 74-year-old woman with diffuse infiltration of gastric adenocarcinoma (signet-ring-cell carcinoma/poorly differentiated adenocarcinoma) cells in the thyroid. The pathological diagnosis was made based on upper gastrointestinal endoscopy with biopsy and fine-needle aspiration cytology of the thyroid. An 18F-FDG PET/CT revealed multiple lesions with increased uptake, including the bilateral thyroid gland. On thyroid ultrasound examination, diffuse enlargement with internal heterogeneity and hypoechoic reticular lines was observed. On color Doppler imaging, a blood-flow signal was not detected in these hypoechoic lines. These findings were similar to those of diffuse metastases caused by other primary cancers, such as lung cancer, as reported earlier. Therefore, the presence of hypoechoic reticular lines without blood-flow signals is probably common to diffuse thyroid metastasis from any origin and an important diagnostic finding. This is the first report to show detailed ultrasound findings of diffuse gastric cancer metastasis to the thyroid gland using color Doppler. Springer Japan 2016-10-01 2017 /pmc/articles/PMC5222898/ /pubmed/27696013 http://dx.doi.org/10.1007/s10396-016-0746-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Morita, Koji
Sakamoto, Takahiko
Ota, Shuji
Masugi, Hideo
Chikuta, Ikumi
Mashimo, Yamato
Edo, Naoki
Tokairin, Takuo
Seki, Nobuhiko
Ishikawa, Toshio
Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland
title Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland
title_full Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland
title_fullStr Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland
title_full_unstemmed Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland
title_short Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland
title_sort ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222898/
https://www.ncbi.nlm.nih.gov/pubmed/27696013
http://dx.doi.org/10.1007/s10396-016-0746-5
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