Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study

Despite limited and ambiguous empirical data, substance use-related problems have been assumed to be rare among patients with autism spectrum disorders (ASD). Using Swedish population-based registers we identified 26,986 individuals diagnosed with ASD during 1973–2009, and their 96,557 non-ASD relat...

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Detalles Bibliográficos
Autores principales: Butwicka, Agnieszka, Långström, Niklas, Larsson, Henrik, Lundström, Sebastian, Serlachius, Eva, Almqvist, Catarina, Frisén, Louise, Lichtenstein, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222913/
https://www.ncbi.nlm.nih.gov/pubmed/27734228
http://dx.doi.org/10.1007/s10803-016-2914-2
Descripción
Sumario:Despite limited and ambiguous empirical data, substance use-related problems have been assumed to be rare among patients with autism spectrum disorders (ASD). Using Swedish population-based registers we identified 26,986 individuals diagnosed with ASD during 1973–2009, and their 96,557 non-ASD relatives. ASD, without diagnosed comorbidity of attention deficit hyperactivity disorder (ADHD) or intellectual disability, was related to a doubled risk of substance use-related problems. The risk of substance use-related problems was the highest among individuals with ASD and ADHD. Further, risks of substance use-related problems were increased among full siblings of ASD probands, half-siblings and parents. We conclude that ASD is a risk factor for substance use-related problems. The elevated risks among relatives of probands with ASD suggest shared familial (genetic and/or shared environmental) liability. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10803-016-2914-2) contains supplementary material, which is available to authorized users.

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