Synergistic interplay of Gβγ and phosphatidylinositol 4,5-bisphosphate dictates Kv7.4 channel activity

Kv7.4 channels are key determinants of arterial contractility and cochlear mechanosensation that, like all Kv7 channels, have an obligatory requirement for phosphatidylinositol 4,5-bisphosphate (PIP(2)). βγ G proteins (Gβγ) have been identified as novel positive regulators of Kv7.4. The present stud...

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Detalles Bibliográficos
Autores principales: Povstyan, Oleksandr V., Barrese, Vincenzo, Stott, Jennifer B, Greenwood, Iain A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Ion Channels, Receptors and Transporters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222924/
https://www.ncbi.nlm.nih.gov/pubmed/27981364
http://dx.doi.org/10.1007/s00424-016-1916-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222924/
https://www.ncbi.nlm.nih.gov/pubmed/27981364
http://dx.doi.org/10.1007/s00424-016-1916-4

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