Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapy

INTRODUCTION: Immunotherapy may be an excellent choice for treating osteosarcoma given its exceptionally high genomic instability, potentially generating neoantigens. In this study, we aim to investigate the HLA class I expression, PD-L1 and tumour-infiltrating lymphocytes in primary osteosarcomas a...

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Detalles Bibliográficos
Autores principales: Sundara, Yayan T., Kostine, Marie, Cleven, Arjen H. G., Bovée, Judith V. M. G., Schilham, Marco W., Cleton-Jansen, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222929/
https://www.ncbi.nlm.nih.gov/pubmed/27853827
http://dx.doi.org/10.1007/s00262-016-1925-3

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