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The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries
Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222948/ https://www.ncbi.nlm.nih.gov/pubmed/27590903 http://dx.doi.org/10.1007/s10519-016-9809-z |
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author | Maciejewski, Dominique F. Renteria, Miguel E. Abdellaoui, Abdel Medland, Sarah E. Few, Lauren R. Gordon, Scott D. Madden, Pamela A.F. Montgomery, Grant Trull, Timothy J. Heath, Andrew C. Statham, Dixie J. Martin, Nicholas G. Zietsch, Brendan P. Verweij, Karin J.H. |
author_facet | Maciejewski, Dominique F. Renteria, Miguel E. Abdellaoui, Abdel Medland, Sarah E. Few, Lauren R. Gordon, Scott D. Madden, Pamela A.F. Montgomery, Grant Trull, Timothy J. Heath, Andrew C. Statham, Dixie J. Martin, Nicholas G. Zietsch, Brendan P. Verweij, Karin J.H. |
author_sort | Maciejewski, Dominique F. |
collection | PubMed |
description | Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI. |
format | Online Article Text |
id | pubmed-5222948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-52229482017-01-19 The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries Maciejewski, Dominique F. Renteria, Miguel E. Abdellaoui, Abdel Medland, Sarah E. Few, Lauren R. Gordon, Scott D. Madden, Pamela A.F. Montgomery, Grant Trull, Timothy J. Heath, Andrew C. Statham, Dixie J. Martin, Nicholas G. Zietsch, Brendan P. Verweij, Karin J.H. Behav Genet Original Research Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI. Springer US 2016-09-02 2017 /pmc/articles/PMC5222948/ /pubmed/27590903 http://dx.doi.org/10.1007/s10519-016-9809-z Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Research Maciejewski, Dominique F. Renteria, Miguel E. Abdellaoui, Abdel Medland, Sarah E. Few, Lauren R. Gordon, Scott D. Madden, Pamela A.F. Montgomery, Grant Trull, Timothy J. Heath, Andrew C. Statham, Dixie J. Martin, Nicholas G. Zietsch, Brendan P. Verweij, Karin J.H. The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries |
title | The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries |
title_full | The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries |
title_fullStr | The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries |
title_full_unstemmed | The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries |
title_short | The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries |
title_sort | association of genetic predisposition to depressive symptoms with non-suicidal and suicidal self-injuries |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222948/ https://www.ncbi.nlm.nih.gov/pubmed/27590903 http://dx.doi.org/10.1007/s10519-016-9809-z |
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