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PPARs and Mitochondrial Metabolism: From NAFLD to HCC
Metabolic related diseases, such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD), are widespread threats which bring about a significant burden of deaths worldwide, mainly due to cardiovascular events and cancer. The pathogenesis of these diseases is extremely co...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223052/ https://www.ncbi.nlm.nih.gov/pubmed/28115925 http://dx.doi.org/10.1155/2016/7403230 |
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author | Mello, Tommaso Materozzi, Maria Galli, Andrea |
author_facet | Mello, Tommaso Materozzi, Maria Galli, Andrea |
author_sort | Mello, Tommaso |
collection | PubMed |
description | Metabolic related diseases, such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD), are widespread threats which bring about a significant burden of deaths worldwide, mainly due to cardiovascular events and cancer. The pathogenesis of these diseases is extremely complex, multifactorial, and only partially understood. As the main metabolic organ, the liver is central to maintain whole body energetic homeostasis. At the cellular level, mitochondria are the metabolic hub connecting and integrating all the main biochemical, hormonal, and inflammatory signaling pathways to fulfill the energetic and biosynthetic demand of the cell. In the liver, mitochondria metabolism needs to cope with the energetic regulation of the whole body. The nuclear receptors PPARs orchestrate lipid and glucose metabolism and are involved in a variety of diseases, from metabolic disorders to cancer. In this review, focus is placed on the roles of PPARs in the regulation of liver mitochondrial metabolism in physiology and pathology, from NAFLD to HCC. |
format | Online Article Text |
id | pubmed-5223052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-52230522017-01-23 PPARs and Mitochondrial Metabolism: From NAFLD to HCC Mello, Tommaso Materozzi, Maria Galli, Andrea PPAR Res Review Article Metabolic related diseases, such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD), are widespread threats which bring about a significant burden of deaths worldwide, mainly due to cardiovascular events and cancer. The pathogenesis of these diseases is extremely complex, multifactorial, and only partially understood. As the main metabolic organ, the liver is central to maintain whole body energetic homeostasis. At the cellular level, mitochondria are the metabolic hub connecting and integrating all the main biochemical, hormonal, and inflammatory signaling pathways to fulfill the energetic and biosynthetic demand of the cell. In the liver, mitochondria metabolism needs to cope with the energetic regulation of the whole body. The nuclear receptors PPARs orchestrate lipid and glucose metabolism and are involved in a variety of diseases, from metabolic disorders to cancer. In this review, focus is placed on the roles of PPARs in the regulation of liver mitochondrial metabolism in physiology and pathology, from NAFLD to HCC. Hindawi Publishing Corporation 2016 2016-12-27 /pmc/articles/PMC5223052/ /pubmed/28115925 http://dx.doi.org/10.1155/2016/7403230 Text en Copyright © 2016 Tommaso Mello et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mello, Tommaso Materozzi, Maria Galli, Andrea PPARs and Mitochondrial Metabolism: From NAFLD to HCC |
title | PPARs and Mitochondrial Metabolism: From NAFLD to HCC |
title_full | PPARs and Mitochondrial Metabolism: From NAFLD to HCC |
title_fullStr | PPARs and Mitochondrial Metabolism: From NAFLD to HCC |
title_full_unstemmed | PPARs and Mitochondrial Metabolism: From NAFLD to HCC |
title_short | PPARs and Mitochondrial Metabolism: From NAFLD to HCC |
title_sort | ppars and mitochondrial metabolism: from nafld to hcc |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223052/ https://www.ncbi.nlm.nih.gov/pubmed/28115925 http://dx.doi.org/10.1155/2016/7403230 |
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