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Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
BACKGROUND: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223080/ https://www.ncbi.nlm.nih.gov/pubmed/28123324 http://dx.doi.org/10.1016/j.jgr.2016.01.001 |
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author | Hwang, Eunson Park, Sang-Yong Yin, Chang Shik Kim, Hee-Taek Kim, Yong Min Yi, Tae Hoo |
author_facet | Hwang, Eunson Park, Sang-Yong Yin, Chang Shik Kim, Hee-Taek Kim, Yong Min Yi, Tae Hoo |
author_sort | Hwang, Eunson |
collection | PubMed |
description | BACKGROUND: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. METHODS: Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. RESULTS: In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. CONCLUSION: These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. |
format | Online Article Text |
id | pubmed-5223080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-52230802017-01-25 Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin Hwang, Eunson Park, Sang-Yong Yin, Chang Shik Kim, Hee-Taek Kim, Yong Min Yi, Tae Hoo J Ginseng Res Research Article BACKGROUND: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. METHODS: Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. RESULTS: In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. CONCLUSION: These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. Elsevier 2017-01 2016-01-12 /pmc/articles/PMC5223080/ /pubmed/28123324 http://dx.doi.org/10.1016/j.jgr.2016.01.001 Text en Copyright © 2016, The Korean Society of Ginseng, Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Hwang, Eunson Park, Sang-Yong Yin, Chang Shik Kim, Hee-Taek Kim, Yong Min Yi, Tae Hoo Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin |
title | Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin |
title_full | Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin |
title_fullStr | Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin |
title_full_unstemmed | Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin |
title_short | Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin |
title_sort | antiaging effects of the mixture of panax ginseng and crataegus pinnatifida in human dermal fibroblasts and healthy human skin |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223080/ https://www.ncbi.nlm.nih.gov/pubmed/28123324 http://dx.doi.org/10.1016/j.jgr.2016.01.001 |
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