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Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin

BACKGROUND: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of...

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Autores principales: Hwang, Eunson, Park, Sang-Yong, Yin, Chang Shik, Kim, Hee-Taek, Kim, Yong Min, Yi, Tae Hoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223080/
https://www.ncbi.nlm.nih.gov/pubmed/28123324
http://dx.doi.org/10.1016/j.jgr.2016.01.001
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author Hwang, Eunson
Park, Sang-Yong
Yin, Chang Shik
Kim, Hee-Taek
Kim, Yong Min
Yi, Tae Hoo
author_facet Hwang, Eunson
Park, Sang-Yong
Yin, Chang Shik
Kim, Hee-Taek
Kim, Yong Min
Yi, Tae Hoo
author_sort Hwang, Eunson
collection PubMed
description BACKGROUND: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. METHODS: Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. RESULTS: In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. CONCLUSION: These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin.
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spelling pubmed-52230802017-01-25 Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin Hwang, Eunson Park, Sang-Yong Yin, Chang Shik Kim, Hee-Taek Kim, Yong Min Yi, Tae Hoo J Ginseng Res Research Article BACKGROUND: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. METHODS: Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. RESULTS: In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. CONCLUSION: These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. Elsevier 2017-01 2016-01-12 /pmc/articles/PMC5223080/ /pubmed/28123324 http://dx.doi.org/10.1016/j.jgr.2016.01.001 Text en Copyright © 2016, The Korean Society of Ginseng, Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Hwang, Eunson
Park, Sang-Yong
Yin, Chang Shik
Kim, Hee-Taek
Kim, Yong Min
Yi, Tae Hoo
Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
title Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
title_full Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
title_fullStr Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
title_full_unstemmed Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
title_short Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
title_sort antiaging effects of the mixture of panax ginseng and crataegus pinnatifida in human dermal fibroblasts and healthy human skin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223080/
https://www.ncbi.nlm.nih.gov/pubmed/28123324
http://dx.doi.org/10.1016/j.jgr.2016.01.001
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