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High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

Epigenetic factors have been suggested to play an important role in metabolic memory by trapping and maintaining initial metabolic changes within the transcriptional regulatory machinery. In this study we fed mice a high fat diet (HFD) for seven weeks followed by additional five weeks of chow, to id...

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Detalles Bibliográficos
Autores principales: Siersbæk, Majken, Varticovski, Lyuba, Yang, Shutong, Baek, Songjoon, Nielsen, Ronni, Mandrup, Susanne, Hager, Gordon L., Chung, Jay H., Grøntved, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223143/
https://www.ncbi.nlm.nih.gov/pubmed/28071704
http://dx.doi.org/10.1038/srep40220