Tryptophan and Non-Tryptophan Fluorescence of the Eye Lens Proteins Provides Diagnostics of Cataract at the Molecular Level

The chemical nature of the non-tryptophan (non-Trp) fluorescence of porcine and human eye lens proteins was identified by Mass Spectrometry (MS) and Fluorescence Steady-State and Lifetime spectroscopy as post-translational modifications (PTM) of Trp and Arg amino acid residues. Fluorescence intensit...

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Detalles Bibliográficos
Autores principales: Gakamsky, Anna, Duncan, Rory R., Howarth, Nicola M., Dhillon, Baljean, Buttenschön, Kim K., Daly, Daniel J., Gakamsky, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223181/
https://www.ncbi.nlm.nih.gov/pubmed/28071717
http://dx.doi.org/10.1038/srep40375

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