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In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions

Zebrafish is fast becoming a species of choice in biomedical research for the investigation of functional and dysfunctional processes coupled with their genetic and pharmacological modulation. As with mammals, experimentation with zebrafish constitutes a complicated ethical issue that calls for the...

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Autores principales: Mwaffo, Violet, Butail, Sachit, Porfiri, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223199/
https://www.ncbi.nlm.nih.gov/pubmed/28071731
http://dx.doi.org/10.1038/srep39877
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author Mwaffo, Violet
Butail, Sachit
Porfiri, Maurizio
author_facet Mwaffo, Violet
Butail, Sachit
Porfiri, Maurizio
author_sort Mwaffo, Violet
collection PubMed
description Zebrafish is fast becoming a species of choice in biomedical research for the investigation of functional and dysfunctional processes coupled with their genetic and pharmacological modulation. As with mammals, experimentation with zebrafish constitutes a complicated ethical issue that calls for the exploration of alternative testing methods to reduce the number of subjects, refine experimental designs, and replace live animals. Inspired by the demonstrated advantages of computational studies in other life science domains, we establish an authentic data-driven modelling framework to simulate zebrafish swimming in three dimensions. The model encapsulates burst-and-coast swimming style, speed modulation, and wall interaction, laying the foundations for in-silico experiments of zebrafish behaviour. Through computational studies, we demonstrate the ability of the model to replicate common ethological observables such as speed and spatial preference, and anticipate experimental observations on the correlation between tank dimensions on zebrafish behaviour. Reaching to other experimental paradigms, our framework is expected to contribute to a reduction in animal use and suffering.
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spelling pubmed-52231992017-01-17 In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions Mwaffo, Violet Butail, Sachit Porfiri, Maurizio Sci Rep Article Zebrafish is fast becoming a species of choice in biomedical research for the investigation of functional and dysfunctional processes coupled with their genetic and pharmacological modulation. As with mammals, experimentation with zebrafish constitutes a complicated ethical issue that calls for the exploration of alternative testing methods to reduce the number of subjects, refine experimental designs, and replace live animals. Inspired by the demonstrated advantages of computational studies in other life science domains, we establish an authentic data-driven modelling framework to simulate zebrafish swimming in three dimensions. The model encapsulates burst-and-coast swimming style, speed modulation, and wall interaction, laying the foundations for in-silico experiments of zebrafish behaviour. Through computational studies, we demonstrate the ability of the model to replicate common ethological observables such as speed and spatial preference, and anticipate experimental observations on the correlation between tank dimensions on zebrafish behaviour. Reaching to other experimental paradigms, our framework is expected to contribute to a reduction in animal use and suffering. Nature Publishing Group 2017-01-10 /pmc/articles/PMC5223199/ /pubmed/28071731 http://dx.doi.org/10.1038/srep39877 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Mwaffo, Violet
Butail, Sachit
Porfiri, Maurizio
In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions
title In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions
title_full In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions
title_fullStr In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions
title_full_unstemmed In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions
title_short In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions
title_sort in-silico experiments of zebrafish behaviour: modeling swimming in three dimensions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223199/
https://www.ncbi.nlm.nih.gov/pubmed/28071731
http://dx.doi.org/10.1038/srep39877
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