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In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions
Zebrafish is fast becoming a species of choice in biomedical research for the investigation of functional and dysfunctional processes coupled with their genetic and pharmacological modulation. As with mammals, experimentation with zebrafish constitutes a complicated ethical issue that calls for the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223199/ https://www.ncbi.nlm.nih.gov/pubmed/28071731 http://dx.doi.org/10.1038/srep39877 |
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author | Mwaffo, Violet Butail, Sachit Porfiri, Maurizio |
author_facet | Mwaffo, Violet Butail, Sachit Porfiri, Maurizio |
author_sort | Mwaffo, Violet |
collection | PubMed |
description | Zebrafish is fast becoming a species of choice in biomedical research for the investigation of functional and dysfunctional processes coupled with their genetic and pharmacological modulation. As with mammals, experimentation with zebrafish constitutes a complicated ethical issue that calls for the exploration of alternative testing methods to reduce the number of subjects, refine experimental designs, and replace live animals. Inspired by the demonstrated advantages of computational studies in other life science domains, we establish an authentic data-driven modelling framework to simulate zebrafish swimming in three dimensions. The model encapsulates burst-and-coast swimming style, speed modulation, and wall interaction, laying the foundations for in-silico experiments of zebrafish behaviour. Through computational studies, we demonstrate the ability of the model to replicate common ethological observables such as speed and spatial preference, and anticipate experimental observations on the correlation between tank dimensions on zebrafish behaviour. Reaching to other experimental paradigms, our framework is expected to contribute to a reduction in animal use and suffering. |
format | Online Article Text |
id | pubmed-5223199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52231992017-01-17 In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions Mwaffo, Violet Butail, Sachit Porfiri, Maurizio Sci Rep Article Zebrafish is fast becoming a species of choice in biomedical research for the investigation of functional and dysfunctional processes coupled with their genetic and pharmacological modulation. As with mammals, experimentation with zebrafish constitutes a complicated ethical issue that calls for the exploration of alternative testing methods to reduce the number of subjects, refine experimental designs, and replace live animals. Inspired by the demonstrated advantages of computational studies in other life science domains, we establish an authentic data-driven modelling framework to simulate zebrafish swimming in three dimensions. The model encapsulates burst-and-coast swimming style, speed modulation, and wall interaction, laying the foundations for in-silico experiments of zebrafish behaviour. Through computational studies, we demonstrate the ability of the model to replicate common ethological observables such as speed and spatial preference, and anticipate experimental observations on the correlation between tank dimensions on zebrafish behaviour. Reaching to other experimental paradigms, our framework is expected to contribute to a reduction in animal use and suffering. Nature Publishing Group 2017-01-10 /pmc/articles/PMC5223199/ /pubmed/28071731 http://dx.doi.org/10.1038/srep39877 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Mwaffo, Violet Butail, Sachit Porfiri, Maurizio In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions |
title | In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions |
title_full | In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions |
title_fullStr | In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions |
title_full_unstemmed | In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions |
title_short | In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions |
title_sort | in-silico experiments of zebrafish behaviour: modeling swimming in three dimensions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223199/ https://www.ncbi.nlm.nih.gov/pubmed/28071731 http://dx.doi.org/10.1038/srep39877 |
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