Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation

Heterozygous mutations or deletions of the human Euchromatin Histone Methyltransferase 1 (EHMT1) gene are the main causes of Kleefstra syndrome, a neurodevelopmental disorder that is characterized by impaired memory, autistic features and mostly severe intellectual disability. Previously, Ehmt1(+/−)...

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Detalles Bibliográficos
Autores principales: Benevento, Marco, Oomen, Charlotte A., Horner, Alexa E., Amiri, Houshang, Jacobs, Tessa, Pauwels, Charlotte, Frega, Monica, Kleefstra, Tjitske, Kopanitsa, Maksym V., Grant, Seth G. N., Bussey, Timothy J., Saksida, Lisa M., Van der Zee, Catharina E.E.M., van Bokhoven, Hans, Glennon, Jeffrey C., Kasri, Nael Nadif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223204/
https://www.ncbi.nlm.nih.gov/pubmed/28071689
http://dx.doi.org/10.1038/srep40284

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