New insights into the GINS complex explain the controversy between existing structural models

GINS is a key component of eukaryotic replicative forks and is composed of four subunits (Sld5, Psf1, Psf2, Psf3). To explain the discrepancy between structural data from crystallography and electron microscopy (EM), we show that GINS is a compact tetramer in solution as observed in crystal structur...

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Detalles Bibliográficos
Autores principales: Carroni, Marta, De March, Matteo, Medagli, Barbara, Krastanova, Ivet, Taylor, Ian A., Amenitsch, Heinz, Araki, Hiroyuchi, Pisani, Francesca M., Patwardhan, Ardan, Onesti, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223209/
https://www.ncbi.nlm.nih.gov/pubmed/28071757
http://dx.doi.org/10.1038/srep40188

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