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Radiotherapy in the management of gist: state of the art and new potential scenarios
BACKGROUND: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable or advanced GIST are poorly responsive to conventional cytotoxic chemotherapy...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223331/ https://www.ncbi.nlm.nih.gov/pubmed/28078078 http://dx.doi.org/10.1186/s13569-016-0065-z |
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author | Gatto, L. Nannini, M. Saponara, M. Di Scioscio, V. Beltramo, G. Frezza, G. P. Ercolani, G. Pinna, A. D. Astolfi, A. Urbini, M. Brandi, G. Biasco, G. Pantaleo, M. A. |
author_facet | Gatto, L. Nannini, M. Saponara, M. Di Scioscio, V. Beltramo, G. Frezza, G. P. Ercolani, G. Pinna, A. D. Astolfi, A. Urbini, M. Brandi, G. Biasco, G. Pantaleo, M. A. |
author_sort | Gatto, L. |
collection | PubMed |
description | BACKGROUND: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable or advanced GIST are poorly responsive to conventional cytotoxic chemotherapy but the introduction of tyrosine kinase inhibitors (TKIs) marked a revolutionary step in the treatment of these patients, radically improving prognosis and clinical benefit. Historically GIST has been considered radiation-resistant, and the role of radiotherapy in the management of patients with GIST is currently restricted to symptomatic palliation in current treatment guidelines. CASE PRESENTATION: Here we report two patients affected by metastatic GIST, treated with radiotherapy and radiosurgery in combination with TKIs, achieving an unexpected objective response in the first case and a significant clinical benefit associated with a local tumor control of several months in the second case. CONCLUSIONS: These and other successful experiences that are progressively accumulating, open up new scenarios of use of radiation therapy in various settings of treatment. GIST is not universally radioresistant and radiotherapy, especially if combined with molecularly targeted therapy, can improve the outcomes for patients diagnosed with GIST. |
format | Online Article Text |
id | pubmed-5223331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52233312017-01-11 Radiotherapy in the management of gist: state of the art and new potential scenarios Gatto, L. Nannini, M. Saponara, M. Di Scioscio, V. Beltramo, G. Frezza, G. P. Ercolani, G. Pinna, A. D. Astolfi, A. Urbini, M. Brandi, G. Biasco, G. Pantaleo, M. A. Clin Sarcoma Res Case Report BACKGROUND: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable or advanced GIST are poorly responsive to conventional cytotoxic chemotherapy but the introduction of tyrosine kinase inhibitors (TKIs) marked a revolutionary step in the treatment of these patients, radically improving prognosis and clinical benefit. Historically GIST has been considered radiation-resistant, and the role of radiotherapy in the management of patients with GIST is currently restricted to symptomatic palliation in current treatment guidelines. CASE PRESENTATION: Here we report two patients affected by metastatic GIST, treated with radiotherapy and radiosurgery in combination with TKIs, achieving an unexpected objective response in the first case and a significant clinical benefit associated with a local tumor control of several months in the second case. CONCLUSIONS: These and other successful experiences that are progressively accumulating, open up new scenarios of use of radiation therapy in various settings of treatment. GIST is not universally radioresistant and radiotherapy, especially if combined with molecularly targeted therapy, can improve the outcomes for patients diagnosed with GIST. BioMed Central 2017-01-10 /pmc/articles/PMC5223331/ /pubmed/28078078 http://dx.doi.org/10.1186/s13569-016-0065-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Gatto, L. Nannini, M. Saponara, M. Di Scioscio, V. Beltramo, G. Frezza, G. P. Ercolani, G. Pinna, A. D. Astolfi, A. Urbini, M. Brandi, G. Biasco, G. Pantaleo, M. A. Radiotherapy in the management of gist: state of the art and new potential scenarios |
title | Radiotherapy in the management of gist: state of the art and new potential scenarios |
title_full | Radiotherapy in the management of gist: state of the art and new potential scenarios |
title_fullStr | Radiotherapy in the management of gist: state of the art and new potential scenarios |
title_full_unstemmed | Radiotherapy in the management of gist: state of the art and new potential scenarios |
title_short | Radiotherapy in the management of gist: state of the art and new potential scenarios |
title_sort | radiotherapy in the management of gist: state of the art and new potential scenarios |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223331/ https://www.ncbi.nlm.nih.gov/pubmed/28078078 http://dx.doi.org/10.1186/s13569-016-0065-z |
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