Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation

BACKGROUND: The ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role of Fbw7 in diffuse large B-cell lymphoma (DLBCL) development remains unclear. METHODS: We evaluated Fbw7 expression in patient samples of DLBCL using immunohis...

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Detalles Bibliográficos
Autores principales: Yao, Su, Xu, Fangping, Chen, Yu, Ge, Yan, Zhang, Fen, Huang, Huijie, Li, Li, Lin, Danyi, Luo, Xinlan, Xu, Jie, Luo, Donglan, Zhu, Xiaolan, Liu, Yanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223361/
https://www.ncbi.nlm.nih.gov/pubmed/28069035
http://dx.doi.org/10.1186/s13046-016-0476-y

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