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4E-BP is a target of the GCN2–ATF4 pathway during Drosophila development and aging

Reduced amino acid availability attenuates mRNA translation in cells and helps to extend lifespan in model organisms. The amino acid deprivation–activated kinase GCN2 mediates this response in part by phosphorylating eIF2α. In addition, the cap-dependent translational inhibitor 4E-BP is transcriptio...

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Detalles Bibliográficos
Autores principales:	Kang, Min-Ji, Vasudevan, Deepika, Kang, Kwonyoon, Kim, Kyunggon, Park, Jung-Eun, Zhang, Nan, Zeng, Xiaomei, Neubert, Thomas A., Marr, Michael T., Ryoo, Hyung Don
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223598/ https://www.ncbi.nlm.nih.gov/pubmed/27979906 http://dx.doi.org/10.1083/jcb.201511073

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