To use or not to use the force: How B lymphocytes extract surface-tethered antigens

Using an exquisite cell imaging approach based on DNA nanosensors, Spillane and Tolar (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607064) explore how the physical properties of antigen-presenting cell surfaces affect how B cells internalize surface-tethered antigens. Soft and flexible surfac...

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Detalles Bibliográficos
Autores principales: Pierobon, Paolo, Lennon-Duménil, Ana-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223618/
https://www.ncbi.nlm.nih.gov/pubmed/27998992
http://dx.doi.org/10.1083/jcb.201612043
Descripción
Sumario:Using an exquisite cell imaging approach based on DNA nanosensors, Spillane and Tolar (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607064) explore how the physical properties of antigen-presenting cell surfaces affect how B cells internalize surface-tethered antigens. Soft and flexible surfaces promote mechanical force-mediated antigen extraction, whereas stiff surfaces lead to enzyme-mediated antigen release before subsequent internalization.

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