To use or not to use the force: How B lymphocytes extract surface-tethered antigens

Using an exquisite cell imaging approach based on DNA nanosensors, Spillane and Tolar (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607064) explore how the physical properties of antigen-presenting cell surfaces affect how B cells internalize surface-tethered antigens. Soft and flexible surfac...

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Detalles Bibliográficos
Autores principales: Pierobon, Paolo, Lennon-Duménil, Ana-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223618/
https://www.ncbi.nlm.nih.gov/pubmed/27998992
http://dx.doi.org/10.1083/jcb.201612043
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author Pierobon, Paolo
Lennon-Duménil, Ana-Maria
author_facet Pierobon, Paolo
Lennon-Duménil, Ana-Maria
author_sort Pierobon, Paolo
collection PubMed
description Using an exquisite cell imaging approach based on DNA nanosensors, Spillane and Tolar (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607064) explore how the physical properties of antigen-presenting cell surfaces affect how B cells internalize surface-tethered antigens. Soft and flexible surfaces promote mechanical force-mediated antigen extraction, whereas stiff surfaces lead to enzyme-mediated antigen release before subsequent internalization.
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spelling pubmed-52236182017-07-02 To use or not to use the force: How B lymphocytes extract surface-tethered antigens Pierobon, Paolo Lennon-Duménil, Ana-Maria J Cell Biol Commentary Using an exquisite cell imaging approach based on DNA nanosensors, Spillane and Tolar (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607064) explore how the physical properties of antigen-presenting cell surfaces affect how B cells internalize surface-tethered antigens. Soft and flexible surfaces promote mechanical force-mediated antigen extraction, whereas stiff surfaces lead to enzyme-mediated antigen release before subsequent internalization. The Rockefeller University Press 2017-01-02 /pmc/articles/PMC5223618/ /pubmed/27998992 http://dx.doi.org/10.1083/jcb.201612043 Text en © 2017 Pierobon and Lennon-Duménil http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Pierobon, Paolo
Lennon-Duménil, Ana-Maria
To use or not to use the force: How B lymphocytes extract surface-tethered antigens
title To use or not to use the force: How B lymphocytes extract surface-tethered antigens
title_full To use or not to use the force: How B lymphocytes extract surface-tethered antigens
title_fullStr To use or not to use the force: How B lymphocytes extract surface-tethered antigens
title_full_unstemmed To use or not to use the force: How B lymphocytes extract surface-tethered antigens
title_short To use or not to use the force: How B lymphocytes extract surface-tethered antigens
title_sort to use or not to use the force: how b lymphocytes extract surface-tethered antigens
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223618/
https://www.ncbi.nlm.nih.gov/pubmed/27998992
http://dx.doi.org/10.1083/jcb.201612043
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