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Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation
OBJECTIVE: To assess role of some inflammatory mediators in patients with primary and recurrent lumbar disc herniation. Expression of IL-6, transforming growth factor (TGF)-1, insulin-like growth factor (IGF)-1, and Bcl-2-associated X protein (BAX) have been shown to be more intense in the primary g...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurosurgical Society
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223765/ https://www.ncbi.nlm.nih.gov/pubmed/28061491 http://dx.doi.org/10.3340/jkns.2015.0911.002 |
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author | Dagistan, Yasar Cukur, Selma Dagistan, Emine Gezici, Ali Riza |
author_facet | Dagistan, Yasar Cukur, Selma Dagistan, Emine Gezici, Ali Riza |
author_sort | Dagistan, Yasar |
collection | PubMed |
description | OBJECTIVE: To assess role of some inflammatory mediators in patients with primary and recurrent lumbar disc herniation. Expression of IL-6, transforming growth factor (TGF)-1, insulin-like growth factor (IGF)-1, and Bcl-2-associated X protein (BAX) have been shown to be more intense in the primary group than the recurrent goup, but this mediators may be important aspects prognostic. METHODS: 19 patients underwent primary and revision operations between June 1, 2009 and June 1, 2014, and they were included in this study. The 19 patients’ intervertebral disc specimens obtained from the primary procedures and reoperations were evaluated. Expression of IL-6, TGF-1, IGF-1, and BAX were examined immunohistochemically in the 38 biopsy tissues obtained from the primary and recurrent herniated intervertebral discs during the operation. RESULTS: For IL-6 expression in the intervertebral disc specimens, there was no difference between the groups. The immunohistochemical study showed that the intervertebral disc specimens in the primary group were stained intensely by TGF-1 compared with the recurrent group. Expression of IGF-1 in the primary group was found moderate. In contrast, in the recurrent group of patients was mild expression of IGF-1. The primary group intervertebral disc specimens were stained moderately by BAX compared with the recurrent group. CONCLUSION: The results of our prognostic evaluation of patients in the recurrent group who were operated due to disc herniation suggest that mediators may be important parameters. |
format | Online Article Text |
id | pubmed-5223765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-52237652017-01-11 Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation Dagistan, Yasar Cukur, Selma Dagistan, Emine Gezici, Ali Riza J Korean Neurosurg Soc Clinical Article OBJECTIVE: To assess role of some inflammatory mediators in patients with primary and recurrent lumbar disc herniation. Expression of IL-6, transforming growth factor (TGF)-1, insulin-like growth factor (IGF)-1, and Bcl-2-associated X protein (BAX) have been shown to be more intense in the primary group than the recurrent goup, but this mediators may be important aspects prognostic. METHODS: 19 patients underwent primary and revision operations between June 1, 2009 and June 1, 2014, and they were included in this study. The 19 patients’ intervertebral disc specimens obtained from the primary procedures and reoperations were evaluated. Expression of IL-6, TGF-1, IGF-1, and BAX were examined immunohistochemically in the 38 biopsy tissues obtained from the primary and recurrent herniated intervertebral discs during the operation. RESULTS: For IL-6 expression in the intervertebral disc specimens, there was no difference between the groups. The immunohistochemical study showed that the intervertebral disc specimens in the primary group were stained intensely by TGF-1 compared with the recurrent group. Expression of IGF-1 in the primary group was found moderate. In contrast, in the recurrent group of patients was mild expression of IGF-1. The primary group intervertebral disc specimens were stained moderately by BAX compared with the recurrent group. CONCLUSION: The results of our prognostic evaluation of patients in the recurrent group who were operated due to disc herniation suggest that mediators may be important parameters. Korean Neurosurgical Society 2017-01 2016-12-29 /pmc/articles/PMC5223765/ /pubmed/28061491 http://dx.doi.org/10.3340/jkns.2015.0911.002 Text en Copyright © 2017 The Korean Neurosurgical Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Article Dagistan, Yasar Cukur, Selma Dagistan, Emine Gezici, Ali Riza Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation |
title | Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation |
title_full | Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation |
title_fullStr | Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation |
title_full_unstemmed | Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation |
title_short | Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation |
title_sort | role of expression of inflammatory mediators in primary and recurrent lumbar disc herniation |
topic | Clinical Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223765/ https://www.ncbi.nlm.nih.gov/pubmed/28061491 http://dx.doi.org/10.3340/jkns.2015.0911.002 |
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