p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein–Protein Interactions

[Image: see text] The AAA+ ATPase p97/VCP adopts at least three conformations that depend on the binding of ADP and ATP and alter the orientation of the N-terminal protein–protein interaction (PPI) domain into “up” and “down” conformations. Point mutations that cause multisystem proteinopathy 1 (MSP...

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Detalles Bibliográficos
Autores principales: Bulfer, Stacie L., Chou, Tsui-Fen, Arkin, Michelle R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224236/
https://www.ncbi.nlm.nih.gov/pubmed/27267671
http://dx.doi.org/10.1021/acschembio.6b00350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224236/
https://www.ncbi.nlm.nih.gov/pubmed/27267671
http://dx.doi.org/10.1021/acschembio.6b00350

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