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p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein–Protein Interactions
[Image: see text] The AAA+ ATPase p97/VCP adopts at least three conformations that depend on the binding of ADP and ATP and alter the orientation of the N-terminal protein–protein interaction (PPI) domain into “up” and “down” conformations. Point mutations that cause multisystem proteinopathy 1 (MSP...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224236/ https://www.ncbi.nlm.nih.gov/pubmed/27267671 http://dx.doi.org/10.1021/acschembio.6b00350 |