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Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression
OBJECTIVE: To evaluate botulinum toxin serotype A (BoNT-A) effects on sleep problems in children with cerebral palsy (CP) and on mothers’ sleep quality and depression at multiple time points. METHODS: This is a single center, cross sectional, and observational study was conducted to assess children...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Riyadh : Armed Forces Hospital
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224431/ https://www.ncbi.nlm.nih.gov/pubmed/27744462 http://dx.doi.org/10.17712/nsj.2016.4.20160207 |
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author | Safer, Vildan Binay Demir, Sibel Ozbudak Ozkan, Esma Guneri, Fulya Demircioglu |
author_facet | Safer, Vildan Binay Demir, Sibel Ozbudak Ozkan, Esma Guneri, Fulya Demircioglu |
author_sort | Safer, Vildan Binay |
collection | PubMed |
description | OBJECTIVE: To evaluate botulinum toxin serotype A (BoNT-A) effects on sleep problems in children with cerebral palsy (CP) and on mothers’ sleep quality and depression at multiple time points. METHODS: This is a single center, cross sectional, and observational study was conducted to assess children with CP who were admitted. We recruited children with CP who were admitted to Ministry of Health Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey between September 2012 and April 2014 for the BoNT-A injection for lower limb spasticity. Sleep quality of children with CP were determined at baseline and at the first, third and sixth month after the BoNT-A injection. Sleep quality Pittsburgh Sleep Quality Index (PSQI) and depression (by Beck Depression Inventory-II Turkish version) in mothers were also assessed. RESULTS: Twenty-four children with CP (7.05±2.69 years) underwent final assessment. Their bedtime resistance (11.71±3.26 versus (vs) 10±2.75, p<0.01), sleep anxiety (8.00±2.57 vs. 7.13±2.27, p=0.046) and daytime sleepiness (11.67±2.14 vs. 10.25±1.96, p<0.01) were significantly improved in the first month after the BoNT-A injection. In accordance with this, PSQI and BDI scores of the mothers decreased in the first month after the BoNT-A injection. Thereafter, BDI scores continued to decrease, whereas PSQI slightly increased in the third month. CONCLUSIONS: The BoNT-A injection for spasticity in children with CP may have the potential to improve sleep quality in children with CP and their primary caregiver, the mother, as well as to reduce depression in the mother. |
format | Online Article Text |
id | pubmed-5224431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Riyadh : Armed Forces Hospital |
record_format | MEDLINE/PubMed |
spelling | pubmed-52244312017-01-17 Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression Safer, Vildan Binay Demir, Sibel Ozbudak Ozkan, Esma Guneri, Fulya Demircioglu Neurosciences (Riyadh) Original Article OBJECTIVE: To evaluate botulinum toxin serotype A (BoNT-A) effects on sleep problems in children with cerebral palsy (CP) and on mothers’ sleep quality and depression at multiple time points. METHODS: This is a single center, cross sectional, and observational study was conducted to assess children with CP who were admitted. We recruited children with CP who were admitted to Ministry of Health Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey between September 2012 and April 2014 for the BoNT-A injection for lower limb spasticity. Sleep quality of children with CP were determined at baseline and at the first, third and sixth month after the BoNT-A injection. Sleep quality Pittsburgh Sleep Quality Index (PSQI) and depression (by Beck Depression Inventory-II Turkish version) in mothers were also assessed. RESULTS: Twenty-four children with CP (7.05±2.69 years) underwent final assessment. Their bedtime resistance (11.71±3.26 versus (vs) 10±2.75, p<0.01), sleep anxiety (8.00±2.57 vs. 7.13±2.27, p=0.046) and daytime sleepiness (11.67±2.14 vs. 10.25±1.96, p<0.01) were significantly improved in the first month after the BoNT-A injection. In accordance with this, PSQI and BDI scores of the mothers decreased in the first month after the BoNT-A injection. Thereafter, BDI scores continued to decrease, whereas PSQI slightly increased in the third month. CONCLUSIONS: The BoNT-A injection for spasticity in children with CP may have the potential to improve sleep quality in children with CP and their primary caregiver, the mother, as well as to reduce depression in the mother. Riyadh : Armed Forces Hospital 2016-10 /pmc/articles/PMC5224431/ /pubmed/27744462 http://dx.doi.org/10.17712/nsj.2016.4.20160207 Text en Copyright: © Neurosciences https://creativecommons.org/licenses/by/3.0/Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. |
spellingShingle | Original Article Safer, Vildan Binay Demir, Sibel Ozbudak Ozkan, Esma Guneri, Fulya Demircioglu Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression |
title | Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression |
title_full | Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression |
title_fullStr | Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression |
title_full_unstemmed | Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression |
title_short | Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression |
title_sort | effects of botulinum toxin serotype a on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224431/ https://www.ncbi.nlm.nih.gov/pubmed/27744462 http://dx.doi.org/10.17712/nsj.2016.4.20160207 |
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