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Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications
The remarkable clinical success of Fc-fusion proteins has driven intense investigation for even more potent replacements. Using quality-by-design (QbD) approaches, we generated hexameric-Fc (hexa-Fc), a ~20 nm oligomeric Fc-based scaffold that we here show binds low-affinity inhibitory receptors (Fc...
Autores principales: | Czajkowsky, Daniel M., Andersen, Jan Terje, Fuchs, Anja, Wilson, Timothy J., Mekhaiel, David, Colonna, Marco, He, Jianfeng, Shao, Zhifeng, Mitchell, Daniel A., Wu, Gang, Dell, Anne, Haslam, Stuart, Lloyd, Katy A., Moore, Shona C., Sandlie, Inger, Blundell, Patricia A., Pleass, Richard J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224519/ https://www.ncbi.nlm.nih.gov/pubmed/25912958 http://dx.doi.org/10.1038/srep09526 |
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