Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA

Here we described the preparation and characterization by atomic force microscopy of dumbbell-shaped conjugates between 450 bp double-stranded DNA polymer, poly(dG)-poly(dC), and 5 nm gold nanoparticles (GNPs). We have demonstrated that the size of the nanoparticles in the conjugates can be increase...

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Detalles Bibliográficos
Autores principales: Eidelshtein, Gennady, Fattal, Moran, Avishai, Gavriel, Kempinski, Benjamin, Giannini, Clelia, Kotlyar, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224630/
https://www.ncbi.nlm.nih.gov/pubmed/28335294
http://dx.doi.org/10.3390/nano6090167
Descripción
Sumario:Here we described the preparation and characterization by atomic force microscopy of dumbbell-shaped conjugates between 450 bp double-stranded DNA polymer, poly(dG)-poly(dC), and 5 nm gold nanoparticles (GNPs). We have demonstrated that the size of the nanoparticles in the conjugates can be increased in a controlled fashion. Application of the conjugates for measuring the electrical conductivity of DNA is discussed.

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