Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA

Here we described the preparation and characterization by atomic force microscopy of dumbbell-shaped conjugates between 450 bp double-stranded DNA polymer, poly(dG)-poly(dC), and 5 nm gold nanoparticles (GNPs). We have demonstrated that the size of the nanoparticles in the conjugates can be increase...

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Autores principales: Eidelshtein, Gennady, Fattal, Moran, Avishai, Gavriel, Kempinski, Benjamin, Giannini, Clelia, Kotlyar, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224630/
https://www.ncbi.nlm.nih.gov/pubmed/28335294
http://dx.doi.org/10.3390/nano6090167
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author Eidelshtein, Gennady
Fattal, Moran
Avishai, Gavriel
Kempinski, Benjamin
Giannini, Clelia
Kotlyar, Alexander
author_facet Eidelshtein, Gennady
Fattal, Moran
Avishai, Gavriel
Kempinski, Benjamin
Giannini, Clelia
Kotlyar, Alexander
author_sort Eidelshtein, Gennady
collection PubMed
description Here we described the preparation and characterization by atomic force microscopy of dumbbell-shaped conjugates between 450 bp double-stranded DNA polymer, poly(dG)-poly(dC), and 5 nm gold nanoparticles (GNPs). We have demonstrated that the size of the nanoparticles in the conjugates can be increased in a controlled fashion. Application of the conjugates for measuring the electrical conductivity of DNA is discussed.
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spelling pubmed-52246302017-03-21 Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA Eidelshtein, Gennady Fattal, Moran Avishai, Gavriel Kempinski, Benjamin Giannini, Clelia Kotlyar, Alexander Nanomaterials (Basel) Article Here we described the preparation and characterization by atomic force microscopy of dumbbell-shaped conjugates between 450 bp double-stranded DNA polymer, poly(dG)-poly(dC), and 5 nm gold nanoparticles (GNPs). We have demonstrated that the size of the nanoparticles in the conjugates can be increased in a controlled fashion. Application of the conjugates for measuring the electrical conductivity of DNA is discussed. MDPI 2016-09-08 /pmc/articles/PMC5224630/ /pubmed/28335294 http://dx.doi.org/10.3390/nano6090167 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Eidelshtein, Gennady
Fattal, Moran
Avishai, Gavriel
Kempinski, Benjamin
Giannini, Clelia
Kotlyar, Alexander
Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA
title Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA
title_full Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA
title_fullStr Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA
title_full_unstemmed Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA
title_short Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA
title_sort preparation, characterization and manipulation of conjugates between gold nanoparticles and dna
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224630/
https://www.ncbi.nlm.nih.gov/pubmed/28335294
http://dx.doi.org/10.3390/nano6090167
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