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Recent advances in understanding and managing liver transplantation
Liver transplantation (LT) has been established as the most effective treatment modality for end-stage liver disease over the last few decades. Currently, patient and graft survival after LT are excellent, with 1- and 5-year survival of 90% and 80%, respectively. However, the timing of referral to L...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224676/ https://www.ncbi.nlm.nih.gov/pubmed/28105300 http://dx.doi.org/10.12688/f1000research.8768.1 |
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author | Russo, Francesco Paolo Ferrarese, Alberto Zanetto, Alberto |
author_facet | Russo, Francesco Paolo Ferrarese, Alberto Zanetto, Alberto |
author_sort | Russo, Francesco Paolo |
collection | PubMed |
description | Liver transplantation (LT) has been established as the most effective treatment modality for end-stage liver disease over the last few decades. Currently, patient and graft survival after LT are excellent, with 1- and 5-year survival of 90% and 80%, respectively. However, the timing of referral to LT is crucial for improving survival benefit and outcome. The current shortage of donors and the increasing demand for LT currently lengthen the waiting time. Thus, waiting list mortality is about 10–15%, according to the geographical area. For this reason, over the last several years, alternatives to deceased donor LT and new options for prioritizing patients on the waiting list have been proposed. |
format | Online Article Text |
id | pubmed-5224676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-52246762017-01-18 Recent advances in understanding and managing liver transplantation Russo, Francesco Paolo Ferrarese, Alberto Zanetto, Alberto F1000Res Review Liver transplantation (LT) has been established as the most effective treatment modality for end-stage liver disease over the last few decades. Currently, patient and graft survival after LT are excellent, with 1- and 5-year survival of 90% and 80%, respectively. However, the timing of referral to LT is crucial for improving survival benefit and outcome. The current shortage of donors and the increasing demand for LT currently lengthen the waiting time. Thus, waiting list mortality is about 10–15%, according to the geographical area. For this reason, over the last several years, alternatives to deceased donor LT and new options for prioritizing patients on the waiting list have been proposed. F1000Research 2016-12-21 /pmc/articles/PMC5224676/ /pubmed/28105300 http://dx.doi.org/10.12688/f1000research.8768.1 Text en Copyright: © 2016 Russo FP et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Russo, Francesco Paolo Ferrarese, Alberto Zanetto, Alberto Recent advances in understanding and managing liver transplantation |
title | Recent advances in understanding and managing liver transplantation |
title_full | Recent advances in understanding and managing liver transplantation |
title_fullStr | Recent advances in understanding and managing liver transplantation |
title_full_unstemmed | Recent advances in understanding and managing liver transplantation |
title_short | Recent advances in understanding and managing liver transplantation |
title_sort | recent advances in understanding and managing liver transplantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224676/ https://www.ncbi.nlm.nih.gov/pubmed/28105300 http://dx.doi.org/10.12688/f1000research.8768.1 |
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