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Respiratory syncytial virus infection: an innate perspective

Respiratory syncytial virus (RSV) is a common cause of upper respiratory tract infection in children and adults. However, infection with this virus sometimes leads to severe lower respiratory disease and is the major cause of infant hospitalisations in the developed world. Several risk factors such...

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Detalles Bibliográficos
Autor principal: Johansson, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224685/
https://www.ncbi.nlm.nih.gov/pubmed/28105323
http://dx.doi.org/10.12688/f1000research.9637.1
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author Johansson, Cecilia
author_facet Johansson, Cecilia
author_sort Johansson, Cecilia
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description Respiratory syncytial virus (RSV) is a common cause of upper respiratory tract infection in children and adults. However, infection with this virus sometimes leads to severe lower respiratory disease and is the major cause of infant hospitalisations in the developed world. Several risk factors such as baby prematurity and congenital heart disease are known to predispose towards severe disease but previously healthy, full-term infants can also develop bronchiolitis and viral pneumonia during RSV infection. The causes of severe disease are not fully understood but may include dysregulation of the immune response to the virus, resulting in excessive recruitment and activation of innate and adaptive immune cells that can cause damage. This review highlights recent discoveries on the balancing act of immune-mediated virus clearance versus immunopathology during RSV infection.
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spelling pubmed-52246852017-01-18 Respiratory syncytial virus infection: an innate perspective Johansson, Cecilia F1000Res Review Respiratory syncytial virus (RSV) is a common cause of upper respiratory tract infection in children and adults. However, infection with this virus sometimes leads to severe lower respiratory disease and is the major cause of infant hospitalisations in the developed world. Several risk factors such as baby prematurity and congenital heart disease are known to predispose towards severe disease but previously healthy, full-term infants can also develop bronchiolitis and viral pneumonia during RSV infection. The causes of severe disease are not fully understood but may include dysregulation of the immune response to the virus, resulting in excessive recruitment and activation of innate and adaptive immune cells that can cause damage. This review highlights recent discoveries on the balancing act of immune-mediated virus clearance versus immunopathology during RSV infection. F1000Research 2016-12-21 /pmc/articles/PMC5224685/ /pubmed/28105323 http://dx.doi.org/10.12688/f1000research.9637.1 Text en Copyright: © 2016 Johansson C http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Johansson, Cecilia
Respiratory syncytial virus infection: an innate perspective
title Respiratory syncytial virus infection: an innate perspective
title_full Respiratory syncytial virus infection: an innate perspective
title_fullStr Respiratory syncytial virus infection: an innate perspective
title_full_unstemmed Respiratory syncytial virus infection: an innate perspective
title_short Respiratory syncytial virus infection: an innate perspective
title_sort respiratory syncytial virus infection: an innate perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224685/
https://www.ncbi.nlm.nih.gov/pubmed/28105323
http://dx.doi.org/10.12688/f1000research.9637.1
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