SDF-1α/CXCR4 Signaling in Lipid Rafts Induces Platelet Aggregation via PI3 Kinase-Dependent Akt Phosphorylation

Stromal cell-derived factor-1α (SDF-1α)-induced platelet aggregation is mediated through its G protein-coupled receptor CXCR4 and phosphatidylinositol 3 kinase (PI3K). Here, we demonstrate that SDF-1α induces phosphorylation of Akt at Thr308 and Ser473 in human platelets. SDF-1α-induced platelet agg...

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Detalles Bibliográficos
Autores principales: Ohtsuka, Hiroko, Iguchi, Tomohiro, Hayashi, Moyuru, Kaneda, Mizuho, Iida, Kazuko, Shimonaka, Motoyuki, Hara, Takahiko, Arai, Morio, Koike, Yuichi, Yamamoto, Naomasa, Kasahara, Kohji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224795/
https://www.ncbi.nlm.nih.gov/pubmed/28072855
http://dx.doi.org/10.1371/journal.pone.0169609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224795/
https://www.ncbi.nlm.nih.gov/pubmed/28072855
http://dx.doi.org/10.1371/journal.pone.0169609

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