Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes

OBJECTIVE: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring. RESEARCH DESIGN AND METHODS: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a con...

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Autores principales: Bytoft, Birgitte, Knorr, Sine, Vlachova, Zuzana, Jensen, Rikke B., Mathiesen, Elisabeth R., Beck-Nielsen, Henning, Gravholt, Claus H., Jensen, Dorte M., Clausen, Tine D., Mortensen, Erik L., Damm, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224808/
https://www.ncbi.nlm.nih.gov/pubmed/28072839
http://dx.doi.org/10.1371/journal.pone.0169308
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author Bytoft, Birgitte
Knorr, Sine
Vlachova, Zuzana
Jensen, Rikke B.
Mathiesen, Elisabeth R.
Beck-Nielsen, Henning
Gravholt, Claus H.
Jensen, Dorte M.
Clausen, Tine D.
Mortensen, Erik L.
Damm, Peter
author_facet Bytoft, Birgitte
Knorr, Sine
Vlachova, Zuzana
Jensen, Rikke B.
Mathiesen, Elisabeth R.
Beck-Nielsen, Henning
Gravholt, Claus H.
Jensen, Dorte M.
Clausen, Tine D.
Mortensen, Erik L.
Damm, Peter
author_sort Bytoft, Birgitte
collection PubMed
description OBJECTIVE: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring. RESEARCH DESIGN AND METHODS: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012–2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style. RESULTS: A higher frequency of the exposed offspring had a parent/self-reported use of Attention Deficit Hyperactivity Disorder (ADHD) medication compared to the control group (2.2% vs. 0.0%, p = 0.01). Clinical significant differences between adolescents exposed to maternal diabetes and unexposed controls were not found in either single scores on Conners Continuous Performance Test or on any of the five attention factors identified. CONCLUSIONS: Exposure to maternal type 1 diabetes did not seem to increase the risk of attention deficits in the adolescent offspring. However, a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test.
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spelling pubmed-52248082017-01-31 Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes Bytoft, Birgitte Knorr, Sine Vlachova, Zuzana Jensen, Rikke B. Mathiesen, Elisabeth R. Beck-Nielsen, Henning Gravholt, Claus H. Jensen, Dorte M. Clausen, Tine D. Mortensen, Erik L. Damm, Peter PLoS One Research Article OBJECTIVE: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring. RESEARCH DESIGN AND METHODS: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012–2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style. RESULTS: A higher frequency of the exposed offspring had a parent/self-reported use of Attention Deficit Hyperactivity Disorder (ADHD) medication compared to the control group (2.2% vs. 0.0%, p = 0.01). Clinical significant differences between adolescents exposed to maternal diabetes and unexposed controls were not found in either single scores on Conners Continuous Performance Test or on any of the five attention factors identified. CONCLUSIONS: Exposure to maternal type 1 diabetes did not seem to increase the risk of attention deficits in the adolescent offspring. However, a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test. Public Library of Science 2017-01-10 /pmc/articles/PMC5224808/ /pubmed/28072839 http://dx.doi.org/10.1371/journal.pone.0169308 Text en © 2017 Bytoft et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bytoft, Birgitte
Knorr, Sine
Vlachova, Zuzana
Jensen, Rikke B.
Mathiesen, Elisabeth R.
Beck-Nielsen, Henning
Gravholt, Claus H.
Jensen, Dorte M.
Clausen, Tine D.
Mortensen, Erik L.
Damm, Peter
Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes
title Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes
title_full Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes
title_fullStr Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes
title_full_unstemmed Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes
title_short Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes
title_sort assessment of attention deficits in adolescent offspring exposed to maternal type 1 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224808/
https://www.ncbi.nlm.nih.gov/pubmed/28072839
http://dx.doi.org/10.1371/journal.pone.0169308
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