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Staged anticonvulsant screening for chronic epilepsy

OBJECTIVE: Current anticonvulsant screening programs are based on seizures evoked in normal animals. One‐third of epileptic patients do not respond to the anticonvulsants discovered with these models. We evaluated a tiered program based on chronic epilepsy and spontaneous seizures, with compounds ad...

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Detalles Bibliográficos
Autores principales: Berdichevsky, Yevgeny, Saponjian, Yero, Park, Kyung‐Il, Roach, Bonnie, Pouliot, Wendy, Lu, Kimberly, Swiercz, Waldemar, Dudek, F. Edward, Staley, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224819/
https://www.ncbi.nlm.nih.gov/pubmed/28097203
http://dx.doi.org/10.1002/acn3.364

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