Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy

We analyzed quantitative maps of T (1) and T (2) relaxation times and muscle fat fraction measurements in magnetic resonance imaging of the upper arm skeletal muscles and heart in ambulatory boys with Duchenne muscular dystrophy and age‐range‐matched healthy volunteer boys. The cardiac‐optimized seq...

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Autores principales: Gaur, Lasya, Hanna, Alexander, Bandettini, W. Patricia, Fischbeck, Kenneth H., Arai, Andrew E., Mankodi, Ami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224820/
https://www.ncbi.nlm.nih.gov/pubmed/28097207
http://dx.doi.org/10.1002/acn3.367
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author Gaur, Lasya
Hanna, Alexander
Bandettini, W. Patricia
Fischbeck, Kenneth H.
Arai, Andrew E.
Mankodi, Ami
author_facet Gaur, Lasya
Hanna, Alexander
Bandettini, W. Patricia
Fischbeck, Kenneth H.
Arai, Andrew E.
Mankodi, Ami
author_sort Gaur, Lasya
collection PubMed
description We analyzed quantitative maps of T (1) and T (2) relaxation times and muscle fat fraction measurements in magnetic resonance imaging of the upper arm skeletal muscles and heart in ambulatory boys with Duchenne muscular dystrophy and age‐range‐matched healthy volunteer boys. The cardiac‐optimized sequences detected fatty infiltration and edema in the upper arm skeletal muscles but not the myocardium in these Duchenne muscular dystrophy boys who had normal ejection fraction. Imaging the heart and skeletal muscle using the same magnetic resonance imaging methods during a single scan may be useful in assessing relative disease status and therapeutic response in clinical trials of Duchenne muscular dystrophy.
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spelling pubmed-52248202017-01-17 Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy Gaur, Lasya Hanna, Alexander Bandettini, W. Patricia Fischbeck, Kenneth H. Arai, Andrew E. Mankodi, Ami Ann Clin Transl Neurol Brief Communications We analyzed quantitative maps of T (1) and T (2) relaxation times and muscle fat fraction measurements in magnetic resonance imaging of the upper arm skeletal muscles and heart in ambulatory boys with Duchenne muscular dystrophy and age‐range‐matched healthy volunteer boys. The cardiac‐optimized sequences detected fatty infiltration and edema in the upper arm skeletal muscles but not the myocardium in these Duchenne muscular dystrophy boys who had normal ejection fraction. Imaging the heart and skeletal muscle using the same magnetic resonance imaging methods during a single scan may be useful in assessing relative disease status and therapeutic response in clinical trials of Duchenne muscular dystrophy. John Wiley and Sons Inc. 2016-10-19 /pmc/articles/PMC5224820/ /pubmed/28097207 http://dx.doi.org/10.1002/acn3.367 Text en Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Gaur, Lasya
Hanna, Alexander
Bandettini, W. Patricia
Fischbeck, Kenneth H.
Arai, Andrew E.
Mankodi, Ami
Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy
title Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy
title_full Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy
title_fullStr Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy
title_full_unstemmed Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy
title_short Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy
title_sort upper arm and cardiac magnetic resonance imaging in duchenne muscular dystrophy
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224820/
https://www.ncbi.nlm.nih.gov/pubmed/28097207
http://dx.doi.org/10.1002/acn3.367
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